BPS804 Anti-Sclerostin Antibody in Adults With Moderate Osteogenesis Imperfecta: Results of a Randomized Phase 2a Trial

Author:

Glorieux Francis H1ORCID,Devogelaer Jean-Pierre2,Durigova Michaela1,Goemaere Stefan3,Hemsley Sarah4,Jakob Franz5,Junker Uwe4,Ruckle Jon6,Seefried Lothar5,Winkle Peter J7

Affiliation:

1. Research Centre; Shriners Hospital for Children, and McGill University; Montreal QC Canada

2. Université Catholique de Louvain; Saint-Luc University Hospital; Brussels Belgium

3. Ghent University Hospital; Ghent Belgium

4. Novartis Institutes for BioMedical Research; Basel Switzerland

5. Orthopedic Center for Musculoskeletal Research; Experimental and Clinical Osteology; Orthopedic Department; University of Wuerzburg; Wuerzburg Germany

6. Pacific Pharma Group; Tacoma WA USA

7. Anaheim Clinical Trials; Anaheim CA USA

Funder

Novartis Institutes for BioMedical Research

Noëlle L O'Regan

Mereo BioPharma

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference40 articles.

1. Osteogenesis imperfecta;Glorieux;Best Pract Res Clin Rheumatol,2008

2. DNA sequence analysis in 598 individuals with a clinical diagnosis of osteogenesis imperfecta: diagnostic yield and mutation spectrum;Bardai;Osteoporos Int,2016

3. Osteogenesis imperfecta: recent findings shed new light on this once well-understood condition;Basel;Genet Med. 2009

4. Communicating hydrocephalus, basilar invagination, and other neurologic features in osteogenesis imperfecta;Charnas;Neurology,1993

5. Genetic heterogeneity in osteogenesis imperfecta;Sillence;J Med Genet,1979

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