Affiliation:
1. Department of Organic Chemistry Saint-Petersburg State Chemical and Pharmaceutical University Prof. Popov st., 14 Saint-Petersburg 197376 Russia
2. Research Park St. Petersburg State University Universitetskaya emb., 7–9 Saint-Petersburg 199034 Russia
Abstract
AbstractWe studied a reaction of chromone‐containing acrylonitriles and cyanoacrylates with acid hydrazides. This reaction turned out to be a method for the synthesis of salicyloyl‐substituted 1,2,4‐triazolo[1,5‐a]pyridines. The synthesis developed is a tandem ring‐opening/double ring‐closing process. This synthetic approach is characterized by low toxic solvents (ethanol, butanol) and mediator (Et3N), 37–84% yields, non‐chromatographic isolation of products, and substrate tolerance (59 examples).
Funder
Ministry of Health of the Russian Federation