Affiliation:
1. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 People's Republic of China
Abstract
AbstractRh‐catalyzed asymmetric C(sp3)−H arylation of 8‐benzylquinolines with arylboronic acids was developed. In the presence of 5 mol% BINOL‐derived chiral cyclopentadienyl rhodium complex, asymmetric benzylic C(sp3)−H bond arylation reaction proceeded smoothly to afford a series of enantioenriched triarylmethanes in moderate to good yields with good to excellent enantioselective control (24–89% yields, 63–93% ee). The method displays a broad substrate scope and good functional group tolerance under mild conditions.
Funder
National Natural Science Foundation of China
Science and Technology Commission of Shanghai Municipality