Visible‐Light‐Induced Multicomponent Reaction of Aromatic Aldehydes, Amines and Sodium Difluoromethanesulfinate: Synthesis of CF<sub>2</sub>H‐Substituted Secondary Amines-Reference-Cited by-同舟云学术

Visible‐Light‐Induced Multicomponent Reaction of Aromatic Aldehydes, Amines and Sodium Difluoromethanesulfinate: Synthesis of CF₂H‐Substituted Secondary Amines

Published:2023-10-18 Issue:23 Volume:365 Page:4132-4137
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Zhang Shanshan¹,Geng Yang²,Jiao Jialong¹,Zou Dapeng¹,Wu Yangjie¹^ORCID,Wu Yusheng¹³⁴^ORCID

Affiliation:

1. College of Chemistry Green Catalysis Center Henan Key Laboratory of Chemical Biology and Organic Chemistry Zhengzhou University Zhengzhou 450001 People's Republic of China

2. Department of Pharmacy Zhengzhou Railway Vocational and Technical College Zhengzhou 451460 People's Republic of China

3. TYK Medicines, Inc. Huzhou 313000 People's Republic of China

4. Tetranov International, Inc. 100 Jersey Avenue, Suite A340 New Brunswick NJ 08901 USA

Abstract

AbstractA visible‐light induced multicomponent reaction of aromatic aldehydes, amines and sodium difluoromethanesulfinate for the synthesis of fluorinated secondary amines has been investigated. The protocol affords a convenient pathway for the introduction of difluoromethyl group into imines, which generated in situ by the reaction of aldehydes and amines. A diverse range of fluorinated secondary amines were synthesized in 43%–79% yields under room temperature. In addition, a plausible mechanism was proposed based on several control experiments.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202300822

Reference73 articles.

2. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

3. Nickel‐Catalyzed N‐Arylation of Fluoroalkylamines

5. An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction

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