Affiliation:
1. Department of Chemistry Indian Institute of Science Education and Research (IISER)-Pune Dr. Homi Bhabha Road, Pashan 411008 Pune Maharashtra India
Abstract
AbstractThe palladium (II) catalyzed direct C3‐(sp2)−H alkenylation of five membered heterocyclic aldehydes has been developed using 3‐aminobutanoic acid as a catalytic transient directing group. A wide range of heterocyclic aldehydes reacted with various acrylates to afford highly site‐selective C3‐alkenylated products. This method features an exclusive E‐selective alkenylation at the C3‐position of heterocyclic aldehydes with a broad substrate scope. The protocol also proved to be useful to construct the mechanochromic luminogen.
Funder
Indian Institute of Science Education and Research Pune