Transition‐Metal‐Catalyzed Transformations Involving the Heck Reaction

Author:

Zhang Xue‐Song1,Han Ya‐Ping1ORCID,Zhang Yuecheng1,Liang Yong‐Min2ORCID

Affiliation:

1. School of Chemical Engineering and Technogy Hebei University of Technology Tianjin 300130 People's Republic of China

2. State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 Lanzhou People's Republic of China

Abstract

AbstractElaborated molecular architectures including complex carbocycles, heterocycles, and polycyclic molecular structures represent an important class of organic compounds because they are ubiquitous structural units in a broad variety of biologically and pharmacologically relevant natural products, medicinal molecules, and functional materials. A major challenge in modern synthetic methodology is the development of strategically efficient and selective construction of these compounds from readily available starting materials. Transition‐metal‐catalyzed transformations involving Heck reaction as the pivotal step have afforded a powerful approach for accessing sophisticated polycyclic skeletons from a set of easy‐to handle starting materials, thus highlighting its potential significance in streamlining the drug discovery process. Over the past few decades, significant effort has been devoted to accessing complex polycyclic derivatives in efficient and versatile routes, and a number of powerful and direct synthetic strategies have been reported. In this review, the latest advances in transition‐metal‐catalyzed transformations involving Heck reaction as the critical step are summarized, which could be divided into six categories: 1) Heck/Sonogashira tandem reaction; 2) Heck/Suzuki tandem reaction; 3) Heck/Heck tandem reaction; 4) Heck/Hiyama tandem reaction; 5) Heck/Cacchi tandem reaction; 6) Heck/C−H bond functionalization tandem reaction.

Publisher

Wiley

Subject

General Chemistry

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Azoxy Compounds—From Synthesis to Reagents for Azoxy Group Transfer Reactions;Angewandte Chemie International Edition;2023-10-20

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