Affiliation:
1. College of Chemistry Guangdong University of Petrochemical Technology Maoming Guangdong 525000 People's Republic of China
2. School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 People's Republic of China
Abstract
AbstractA radical‐induced dichloromethylation and concomitant 1,2‐aryl migration of allylic alcohols with CHCl3 is developed for the construction of γ,γ‐dichloroketones in moderate to good yields. We found that, for the para‐substituted unsymmetrical substrates, the more electron‐deficient aryl group migrates preferentially over the more electron‐rich aryl group. Moreover, chlorocyclopropanes could be obtained from allyl alcohols in one‐pot manner through radical‐addition/1,2‐aryl migration/nucleophilic substitution.
Funder
National Natural Science Foundation of China