Apathy in patients with Alzheimer's disease is a cost‐driving factor-Reference-Cited by-同舟云学术

Apathy in patients with Alzheimer's disease is a cost‐driving factor

Published:2023-01-02 Issue:7 Volume:19 Page:2853-2864
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Kruse Christopher¹^ORCID,Maier Franziska²,Spottke Annika³⁴,Bach Jan‐Philipp⁵,Bartels Claudia⁶,Buerger Katharina⁷⁸,Fellgiebel Andreas⁹,Fliessbach Klaus³,Frölich Lutz¹⁰,Hausner Lucrezia¹¹,Hellmich Martin¹¹,Klöppel Stefan¹²,Klostermann Arne¹³¹⁴,Kornhuber Johannes¹⁵,Laske Christoph¹⁶¹⁷,Peters Oliver¹³¹⁴,Priller Josef¹³¹⁸,Richter‐Schmidinger Tanja¹⁵,Schneider Anja³¹⁹,Shah‐Hosseini Kija¹¹,Teipel Stefan²⁰²¹,von Arnim Christine A. F.²²,Wiltfang Jens⁶²³,van der Wurp Hendrik¹²⁴,Dodel Richard¹⁵,Jessen Frank²³²⁵

Affiliation:

1. Department of Geriatric Medicine Center for Translational Neurological and Behavioural Research University Duisburg‐Essen Duisburg Germany

2. Department of Psychiatry University Hospital Cologne, Medical Faculty Cologne Germany

3. German Center for Neurodegenerative Diseases (DZNE) Bonn Germany

4. Department of Neurology University of Bonn Bonn Germany

5. Department of Neurology Philipps‐University Marburg Marburg Germany

6. Department of Psychiatry and Psychotherapy University Medical Center Goettingen (UMG) Georg‐August‐University Goettingen Germany

7. Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig‐Maximilians‐Universität LMU Munich Germany

8. German Center for Neurodegenerative Diseases (DZNE) Munich Germany

9. Center for Mental Health in Old Age, Landeskrankenhaus (AöR) Mainz Germany

10. Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit Mannheim University of Heidelberg Mannheim Germany

11. Institute of Medical Statistics and Computational Biology, Faculty of Medicine University of Cologne Cologne Germany

12. University Hospital of Old Age Psychiatry, University of Bern Bern Switzerland

13. German Center for Neurodegenerative Diseases (DZNE) Berlin Germany

14. Department of Psychiatry Charité Berlin Berlin Germany

15. Department of Psychiatry and Psychotherapy Friedrich Alexander University Erlangen‐Nürnberg Erlangen Germany

16. German Center for Neurodegenerative Diseases (DZNE) Tübingen Germany

17. Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy University of Tübingen Tübingen Germany

18. Department of Neuropsychiatry Charité Berlin & Berlin Institute of Health Berlin Germany

19. Klinik für Neurodegenerative Erkrankungen und Gerontopsychiatrie University of Bonn Bonn Germany

20. German Center for Neurodegenerative Diseases (DZNE) Rostock Germany

21. Department of Psychosomatic Medicine University Hospital of Rostock Rostock Germany

22. Department of Neurology Ulm University Hospital Ulm Germany

23. German Center for Neurodegenerative Diseases (DZNE) Goettingen Germany

24. Department of Statistics TU Dortmund University Dortmund Germany

25. Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD) University of Cologne Cologne Germany

Abstract

AbstractBackgroundApathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on the resource use of DAT patients and their caregivers.MethodsIncluded were baseline data of 107 DAT patients from a randomized clinical trial on apathy treatment. The Resource Utilization in Dementia (RUD) instrument assessed costs over a 1‐month period prior to baseline. Cost predictors were determined via a least absolute shrinkage and selection operator (LASSO).ResultsOn average, total monthly costs were €3070, of which €2711 accounted for caregivers’ and €359 for patients’ costs. An increase of one point in the Apathy Evaluation Scale resulted in a 4.1% increase in total costs.DiscussionApathy is a significant cost driving factor for total costs in mild to moderate DAT. Effective treatment of apathy might be associated with reduced overall costs in DAT.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.12915

Reference60 articles.

1. The worldwide costs of dementia 2015 and comparisons with 2010

2. A Real-World Evidence Analysis of Associations Among Costs, Quality of Life, and Disease-Severity Indicators of Alzheimer’s Disease in Thailand

3. Economic Impact of Dementia by Disease Severity: Exploring the Relationship between Stage of Dementia and Cost of Care in Taiwan

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