Affiliation:
1. Medtronic Sofradim Production Trévoux 01600 France
2. Regenerative, Modular & Developmental Engineering Laboratory (REMODEL) University of Galway Galway H91 TK33 Ireland
3. Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM) University of Galway Galway H91 TK33 Ireland
4. Regenerative, Modular & Developmental Engineering Laboratory (REMODEL) Charles Institute of Dermatology Conway Institute of Biomolecular & Biomedical Research and School of Mechanical & Materials Engineering University College Dublin (UCD) Dublin D04 V1W8 Ireland
Abstract
Cells sense extracellular matrix‐induced biophysical signals, which are transduced into intracellular signaling cascades, and trigger a series of cell responses, including adhesion, migration, and lineage commitment. Traditionally, in in vitro context, monofactorial approaches are employed to control cell fate, despite the fact that in vivo cells are exposed simultaneously to a diverse range of signals. Herein, an overview of key mechanotransduction pathways is first provided. Conventional single‐factor and contemporary multifactorial methodologies, based on substrate rigidity and surface topography, are then reviewed to recapitulate in vitro the in vivo niche, in an attempt to elucidate the underlying mechanisms involved in human mesenchymal stromal cell‐material interactions.
Funder
European Research Council
H2020 Marie Skłodowska-Curie Actions
Science Foundation Ireland