Dementias Platform UK: Bringing genetics into life-Reference-Cited by-同舟云学术

Dementias Platform UK: Bringing genetics into life

Published:2024-03-20 Issue:5 Volume:20 Page:3281-3289
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Leonenko Ganna¹^ORCID,Bauermeister Sarah²,Ghanti Dipanwita²,Stevenson‐Hoare Joshua³,Simmonds Emily¹,Brookes Keeley⁴,Morgan Kevin⁵,Chaturvedi Nishi⁶,Elliott Paul⁷⁸,Thomas Alan⁹,Wareham Nicholas¹⁰,Gallacher John²,Escott‐Price Valentina¹³^ORCID

Affiliation:

1. Dementia Research Institute Cardiff University Cardiff UK

2. Dementias Platform UK Department of Psychiatry University of Oxford Oxford UK

3. Division of Psychological Medicine and Clinical Neurosciences School of Medicine Cardiff University Cardiff UK

4. Biosciences School of Science and Technology Nottingham Trent University Nottingham UK

5. University Nottingham Nottingham UK

6. MRC Unit for Lifelong Health & Ageing, UCL London UK

7. MRC Centre for Environment and Health School of Public Health Imperial College London London UK

8. UK Dementia Research Institute Imperial College London London UK

9. Translational and Clinical Research Institute Newcastle University Newcastle UK

10. MRC Epidemiology Unit University of Cambridge Cambridge UK

Abstract

AbstractINTRODUCTIONThe Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is poorly understood. The DPUK collection of independent cohorts can facilitate research in neurodegeneration by combining their genetic and phenotypic data.METHODSFor genetic data processing, pipelines were generated to perform quality control analysis, genetic imputation, and polygenic risk score (PRS) derivation with six genome‐wide association studies of neurodegenerative diseases. Pipelines were applied to five cohorts.DISCUSSIONThe data processing pipelines, research‐ready imputed genetic data, and PRS scores are now available on the DPUK platform and can be accessed upon request though the DPUK application process. Harmonizing genome‐wide data for multiple datasets increases scientific opportunity and allows the wider research community to access and process data at scale and pace.

Funder

Medical Research Council

Publisher

Wiley

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