Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline-Reference-Cited by-同舟云学术

Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline

Published:2024-01 Issue:1 Volume:16 Page:
ISSN:2352-8729
Container-title:Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
language:en
Short-container-title:Alz & Dem Diag Ass & Dis Mo

Author:

Teipel Stefan J.¹²^ORCID,Dyrba Martin¹,Kleineidam Luca³⁴,Brosseron Frederic³⁴,Levin Fedor¹,Bruno Davide⁵,Buerger Katharina⁶⁷,Cosma Nicoleta⁸,Schneider Luisa‐Sophie⁸,Düzel Emrah⁹¹⁰,Glanz Wenzel⁹,Fliessbach Klaus³⁴,Janowitz Daniel⁷,Kilimann Ingo¹²,Laske Christoph¹¹¹²,Munk Matthias H.¹¹¹³,Maier Franziska¹⁴,Peters Oliver⁸¹⁵,Pomara Nunzio¹⁶¹⁷,Perneczky Robert⁶¹⁸¹⁹²⁰,Rauchmann Boris‐Stephan¹⁸,Priller Josef¹⁵²¹²²²³,Ramirez Alfredo³⁴²⁴²⁵²⁶,Roy Nina³,Schneider Anja³⁴,Spottke Annika³²⁷,Spruth Eike J.¹⁵²¹,Roeske Sandra³,Wagner Michael³⁴,Wiltfang Jens²⁸²⁹³⁰,Wolfsgruber Steffen³⁴,Bartels Claudia²⁹,Jessen Frank³¹⁴²⁴,Heneka Michael T.³⁴³¹,

Affiliation:

1. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Rostock Germany

2. Department of Psychosomatic Medicine University of Rostock Rostock Germany

3. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Bonn Germany

4. Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry University of Bonn Medical Center Bonn Germany

5. School of Psychology Liverpool John Moores University Liverpool UK

6. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Munich Germany

7. Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich Munich Germany

8. Charité – Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany

9. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Magdeburg Germany

10. Institute of Cognitive Neurology and Dementia Research (IKND) Otto‐von‐Guericke University Magdeburg Germany

11. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Tübingen Germany

12. Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy University of Tübingen Tübingen Germany

13. Department of Psychiatry and Psychotherapy University of Tübingen Tübingen Germany

14. Department of Psychiatry University of Cologne Cologne Germany

15. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Berlin Germany

16. Nathan Kline Institute for Psychiatric Research Orangeburg New York USA

17. Department of Psychiatry School of Medicine New York University New York New York USA

18. Department of Psychiatry and Psychotherapy University Hospital LMU Munich Munich Germany

19. Munich Cluster for Systems Neurology (SyNergy) Munich Munich Germany

20. Ageing Epidemiology Research Unit (AGE), School of Public Health Imperial College London London UK

21. Department of Psychiatry and Psychotherapy Charité Berlin Berlin Germany

22. Department of Psychiatry and Psychotherapy Technical University of Munich Munich Germany

23. University of Edinburgh and UK DRI Edinburgh UK

24. Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD), University of Cologne Cologne Germany

25. Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany

26. Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases San Antonio Texas USA

27. Department of Neurology University of Bonn Bonn Germany

28. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Goettingen Germany

29. Department of Psychiatry and Psychotherapy University Medical Center Goettingen, University of Goettingen Goettingen Germany

30. Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED) Department of Medical Sciences University of Aveiro Aveiro Portugal

31. Luxembourg Centre for Systems Biomedicine University of Luxembourg Belval Luxembourg

Abstract

AbstractINTRODUCTIONWe investigated the association of inflammatory mechanisms with markers of Alzheimer's disease (AD) pathology and rates of cognitive decline in the AD spectrum.METHODSWe studied 296 cases from the Deutsches Zentrum für Neurodegenerative Erkrankungen Longitudinal Cognitive Impairment and Dementia Study (DELCODE) cohort, and an extension cohort of 276 cases of the Alzheimer's Disease Neuroimaging Initiative study. Using Bayesian confirmatory factor analysis, we constructed latent factors for synaptic integrity, microglia, cerebrovascular endothelial function, cytokine/chemokine, and complement components of the inflammatory response using a set of inflammatory markers in cerebrospinal fluid.RESULTSWe found strong evidence for an association of synaptic integrity, microglia response, and cerebrovascular endothelial function with a latent factor of AD pathology and with rates of cognitive decline. We found evidence against an association of complement and cytokine/chemokine factors with AD pathology and rates of cognitive decline.DISCUSSIONLatent factors provided access to directly unobservable components of the neuroinflammatory response and their association with AD pathology and cognitive decline.

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

Reference40 articles.

1. Inflammation as a central mechanism in Alzheimer's disease

2. Inflammatory processes in Alzheimer's disease

3. Neuroinflammation in Alzheimer's disease: Current evidence and future directions

4. Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

5. Neuroinflammatory processes in Alzheimer’s disease