Brief webcam test of hand movements predicts episodic memory, executive function, and working memory in a community sample of cognitively asymptomatic older adults

Author:

Li Renjie12ORCID,Wang Xinyi1ORCID,Lawler Katherine13ORCID,Garg Saurabh2ORCID,St George Rebecca J.4ORCID,Bindoff Aidan D.1ORCID,Bartlett Larissa1ORCID,Roccati Eddy1ORCID,King Anna E.1ORCID,Vickers James C.1ORCID,Bai Quan2ORCID,Alty Jane156ORCID

Affiliation:

1. Wicking Dementia Research and Education Centre University of Tasmania Hobart Tasmania Australia

2. School of ICT University of Tasmania Hobart Tasmania Australia

3. School of Allied Health Human Services and Sport La Trobe University Melbourne Victoria Australia

4. School of Psychological Sciences University of Tasmania Hobart Tasmania Australia

5. School of Medicine University of Tasmania Hobart Tasmania Australia

6. Neurology Department Royal Hobart Hospital Hobart Tasmania Australia

Abstract

AbstractINTRODUCTIONLow‐cost simple tests for preclinical Alzheimer's disease are a research priority. We evaluated whether remote unsupervised webcam recordings of finger‐tapping were associated with cognitive performance in older adults.METHODSA total of 404 cognitively‐asymptomatic participants (64.6 [6.77] years; 70.8% female) completed 10‐second finger‐tapping tests (Tasmanian [TAS] Test) and cognitive tests (Cambridge Neuropsychological Test Automated Battery [CANTAB]) online at home. Regression models including hand movement features were compared with null models (comprising age, sex, and education level); change in Akaike Information Criterion greater than 2 (ΔAIC > 2) denoted statistical difference.RESULTSHand movement features improved prediction of episodic memory, executive function, and working memory scores (ΔAIC > 2). Dominant hand features outperformed nondominant hand features for episodic memory (ΔAIC = 2.5), executive function (ΔAIC = 4.8), and working memory (ΔAIC = 2.2).DISCUSSIONThis brief webcam test improved prediction of cognitive performance compared to age, sex, and education. Finger‐tapping holds potential as a remote language‐agnostic screening tool to stratify community cohorts at risk for cognitive decline.

Funder

National Health and Medical Research Council

Publisher

Wiley

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