Effect of CYP 4F2 , VKORC 1 , and CYP 2C9 in Influencing Coumarin Dose: A Single‐Patient Data Meta‐Analysis in More Than 15,000 Individuals

Author:

Danese Elisa1,Raimondi Sara2,Montagnana Martina1,Tagetti Angela2,Langaee Taimour3,Borgiani Paola4,Ciccacci Cinzia4,Carcas Antonio J.56,Borobia Alberto M.56,Tong Hoi Y.56,Dávila‐Fajardo Cristina7,Rodrigues Botton Mariana8,Bourgeois Stephane9,Deloukas Panos910ORCID,Caldwell Michael D.11,Burmester Jim K.12,Berg Richard L.13,Cavallari Larisa H.3,Drozda Katarzyna14,Huang Min15,Zhao Li‐Zi15,Cen Han‐Jing16,Gonzalez‐Conejero Rocio17,Roldan Vanessa17ORCID,Nakamura Yusuke18,Mushiroda Taisei18,Gong Inna Y.19,Kim Richard B.19,Hirai Keita20ORCID,Itoh Kunihiko20,Isaza Carlos21,Beltrán Leonardo2122ORCID,Jiménez‐Varo Enrique23,Cañadas‐Garre Marisa24ORCID,Giontella Alice2,Kringen Marianne K.2526,Haug Kari Bente Foss27,Gwak Hye Sun28ORCID,Lee Kyung Eun29ORCID,Minuz Pietro2ORCID,Lee Ming Ta Michael3031ORCID,Lubitz Steven A.32,Scott Stuart33ORCID,Mazzaccara Cristina3435,Sacchetti Lucia3435,Genç Ece36,Özer Mahmut36,Pathare Anil37,Krishnamoorthy Rajagopal38,Paldi Andras39,Siguret Virginie4041,Loriot Marie‐Anne4243,Kutala Vijay Kumar44,Suarez‐Kurtz Guilherme45,Perini Jamila46,Denny Josh C.47ORCID,Ramirez Andrea H.48,Mittal Balraj49,Rathore Saurabh Singh49,Sagreiya Hersh50,Altman Russ50ORCID,Shahin Mohamed Hossam A.3,Khalifa Sherief I.51,Limdi Nita A.52,Rivers Charles52,Shendre Aditi53ORCID,Dillon Chrisly52,Suriapranata Ivet M.54,Zhou Hong‐Hao55,Tan Sheng‐Lan56,Tatarunas Vacis57,Lesauskaite Vaiva57,Zhang Yumao58ORCID,Maitland‐van der Zee Anke H.5859,Verhoef Talitha I.60,Boer Anthonius58,Taljaard Monica61,Zambon Carlo Federico62ORCID,Pengo Vittorio63,Zhang Jieying Eunice64,Pirmohamed Munir64ORCID,Johnson Julie A.3,Fava Cristiano2ORCID

Affiliation:

1. Clinical Biochemistry SectionDepartment of Neurological, Biomedical and Movement SciencesUniversity of Verona Verona Italy

2. General Medicine and Hypertension UnitDepartment of MedicineUniversity of Verona Verona Italy

3. Department of Pharmacotherapy and Translational ResearchCenter for PharmacogenomicsCollege of PharmacyUniversity of Florida Gainesville Florida USA

4. Genetics SectionDepartment of Biomedicine and PreventionUniversity of Rome “Tor Vergata,” Rome Italy

5. Clinical Pharmacology DepartmentLa Paz University HospitalSchool of MedicineIdiPAZUniversidad Autónoma de Madrid Madrid Spain

6. Spanish Clinical Research Network‐SCReN Madrid Spain

7. Department of Clinical PharmacySan Cecilio University HospitalInstitute for Biomedical Research, IBS Granada Spain

8. Departamento de GenéticaUniversidade Federal do Rio Grande do Sul Porto Alegre Brazil

9. William Harvey Research InstituteBarts & the London Medical SchoolQueen Mary University of London London UK

10. Princess Al‐Jawhara Al‐Brahim Centre of Excellence in Research of Hereditary Disorders (PACER‐HD)King Abdulaziz University Jeddah Saudi Arabia

11. Center for Hyperbaric Medicine and Tissue RepairMarshfield Clinic Marshfield Wisconsin USA

12. Grants Office, Gundersen Health System La Crosse Wisconsin USA

13. Clinical Research CenterMarshfield Clinic Research Foundation Marshfield Wisconsin USA

14. Department of Pharmacy PracticeUniversity of Illinois at Chicago Chicago Illinois USA

15. School of Pharmaceutical SciencesSun Yat‐Sen University Guangzhou China

16. Guangzhou Women and Children's Medical Center Guangzhou China

17. Centro Regional de HemodonaciónHospital Universitario Morales MeseguerUniversidad de Murcia Murcia Spain

18. Research Group for PharmacogenomicsRIKEN Center for Integrative Medical Sciences Yokohama Japan

19. Division of Clinical PharmacologyDepartment of MedicineUniversity of Western Ontario London Ontario Canada

20. Department of Clinical Pharmacology & GeneticsSchool of Pharmaceutical SciencesUniversity of Shizuoka Shizuoka Japan

21. Faculty of Heath SciencesLaboratory of Medical GeneticsUniversidad Tecnológica de Pereira Pereira Colombia

22. Faculty of Heath SciencesUnidad Central del Valle del Cauca Valle del Cauca Colombia

23. Clinical Laboratory DepartmentHospital La Línea Cádiz Spain

24. Centre for Public HealthSchool of Medicine, Dentistry, and Biomedical SciencesQueen's University Belfast Belfast UK

25. Department of PharmacologyOslo University Hospital, Ullevål Oslo Norway

26. Center for PsychopharmacologyDiakonhjemmet Hospital Oslo Norway

27. Department of Medical BiochemistryOslo University Hospital, Ullevål Oslo Norway

28. Division of Life and Pharmaceutical SciencesCollege of PharmacyEwha Womans University Seoul Korea

29. College of PharmacyChungbuk National University Cheongju‐si Korea

30. Genomic Medicine InstituteGeisinger Health System Danville Pennsylvania USA

31. National Center for Genome MedicineInstitute of Biomedical SciencesAcademia Sinica Taipei Taiwan

32. Cardiac Arrhythmia Service & Cardiovascular Research CenterMassachusetts General Hospital Boston Massachusetts USA

33. Department of Genetics and Genomic SciencesIcahn School of Medicine at Mount Sinai New York New York USA

34. CEINGE–Biotecnologie Avanzate s.c.ar.l. Napoli Italy

35. Dipartimento di Medicina Molecolare e Biotecnologie MedicheUniversità di Napoli Federico II Napoli Italy

36. Department of PharmacologyYeditepe University Istanbul Turkey

37. College of Medicine & Health SciencesSultan Qaboos University Muscat Oman

38. INSERM, UMR_S 763 Paris France

39. Ecole Pratique des Hautes Etudes, UMRS_951Genethon Evry France

40. Sorbonne Paris Cité, INSERM, UMR‐S‐1140Université Paris Descartes Paris France

41. Assistance Publique Hôpitaux de ParisHôpital LariboisièreService d'Hématologie Biologique Paris France

42. Sorbonne Paris Cité, INSERM, UMR‐S‐1147Université Paris Descartes Paris France

43. Assistance Publique Hôpitaux de ParisHôpital Européen Georges PompidouService de Biochimie UF Pharmacogénétique et Oncologie Moléculaire Paris France

44. Department of Clinical Pharmacology & TherapeuticsNizam's Institute of Medical Sciences Hyderabad India

45. Coordenação de PesquisaInstituto Nacional de Câncer Rio de Janeiro Brazil

46. Research Laboratory of Pharmaceutical SciencesWest Zone State University‐UEZO Rio de Janeiro Brazil

47. Department of Medicine and Department of Biomedical InformaticsVanderbilt University Nashville Tennessee USA

48. Department of MedicineVanderbilt University Nashville Tennessee USA

49. Department of BiotechnologyBabasaheb Bhimrao Ambedkar University Lucknow India

50. Department of GeneticsStanford University School of Medicine Stanford California USA

51. College of PharmacyGulf Medical University Ajman United Arab Emirates

52. Department of NeurologyUniversity of Alabama at Birmingham Birmingham Alabama USA

53. Department of EpidemiologyRichard M. Fairbanks School of Public HealthIndiana University Purdue University Indianapolis Indiana USA

54. Mochtar Riady Institute for NanotechnologyUniversitas Pelita HarapanLippo Karawaci Tangerang Banten Indonesia

55. Institute of Clinical PharmacologyCentral South University Hunan Sheng China

56. Department of PharmacyXiangya Second HospitalCentral South University Hunan Sheng China

57. Laboratory of Molecular CardiologyInstitute of CardiologyLithuanian University of Health Sciences Kaunas Lithuania

58. Division of Pharmacoepidemiology and Clinical PharmacologyUtrecht Institute for Pharmaceutical SciencesUtrecht University Utrecht The Netherlands

59. Department of Respiratory MedicineAcademic Medical CenterUniversity of Amsterdam Amsterdam The Netherlands

60. Department of Applied Health ResearchUniversity College London London UK

61. Clinica Epidemiology Program and Department of Epidemiology and Community MedicineOttawa Hospital Research InstituteUniversity of Ottawa Ottawa Ontario Canada

62. Department of Medicine‐DIMEDUniversity of Padua Padua Italy

63. Department of Cardiac, Thoracic and Vascular SciencesUniversity of Padua Padua Italy

64. Wolfson Centre for Personalised MedicineDepartment of Molecular and Clinical PharmacologyUniversity of Liverpool Liverpool UK

Funder

British Heart Foundation

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

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