Treatment and survival of patients with occult breast cancer with axillary lymph node metastasis: A nationwide retrospective study

Author:

Sohn Guiyun1,Son Byung Ho1,Lee Soo Jung2,Kang Eun Young3,Jung Sung Hoo4,Cho Se‐Heon5,Baek Seunghee6,Lee Yu Ra1,Kim Hee Jung1,Ko Beom Suk1,Yu 1,Lee Jong Won1,Ahn Sei‐Hyun1

Affiliation:

1. Department of Surgery, College of Medicine University of Ulsan and Asan Medical Center Seoul Korea

2. Department of Surgery Yeungnam University College of Medicine Daegu Korea

3. Breast Care Center Seoul National University Bundang Hospital Seongnam Korea

4. Department of Surgery Chonbuk National University Medical School Jeonju Korea

5. Department of Surgery Dong‐A University College of Medicine Busan Korea

6. Clinical Epidemiology and Biostatistics, College of Medicine University of Ulsan and Asan Medical Center Seoul Korea

Abstract

AbstractBackground and ObjectivesOccult breast cancer (OBC) accounts for 0.3–1.0% of all breast cancers and is a rare presentation of the disease. The present retrospective study examined the overall survival and prognostic factors associated with OBC in Korea.MethodThe study included 142 OBC patients identified from the Korean Breast Cancer Society cancer registry from January 1990 to December2009. All patients had pathologically positive axillary lymph nodes (N1–N3) and pathologically and radiologically negative in‐breast lesions (T0/Tx) based on a retrospective review of the database.ResultsNo statistically significant differences in overall survival were observed between patients undergoing axillary lymph node dissection (ALND) only (80.8%), breast conserving surgery (BCS) with ALND (98.0%), and mastectomy with ALND (92.5%) with P‐value of 0.061. Nodal status was a significant prognostic factor (P = 0.004) on univariate analysis. When compared with T1 patients group, T0/TxN1 patients showed better survival than T1N1 patients (hazard ratio [HR] 0.253; 95% confidence interval, 0.104–0.618; P = 0.003), but T0/TxN2, T0/TxN3 patients showed similar survival to T1N2, T1N3 patients.ConclusionsOBC patients treated with ALND only showed comparable outcomes to those undergoing ALND combined with BCS or mastectomy. Nodal status may be an independent predictor of poor outcome in OBC patients. J. Surg. Oncol. 2014 110:270–274. © 2014 Wiley Periodicals, Inc.

Funder

Korea Breast Cancer Foundation (2012)

Publisher

Wiley

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