HPLC-MS/MS analysis of peramivir in rat plasma: Elimination of matrix effect using the phospholipid-removal solid-phase extraction method

Author:

Lei Mingdao12,Gan Wei2,Sun Yongbing2ORCID

Affiliation:

1. Department of Pharmacy, Jiangxi Maternal and Child Health Hospital; Nanchang China

2. Division of Pharmaceutics, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine; Jiangxi University of Traditional Chinese Medicine; Nanchang China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference18 articles.

1. Anti-influenza virus activity of peramivir in mice with single intramuscular injection;Bantia;Antiviral Research,2006

2. Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: Randomized, controlled trials for prophylaxis and treatment;Barroso;Antiviral Therapy,2005

3. The impact of phospholipids and phospholipid removal on bioanalytical method performance;Carmical;Biomedical Chromatography,2016

4. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analysis;Chambers;Journal of Chromatography B,2007

5. Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing;Drusano;Antimicrobial Agents and Chemotherapy,2001

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