Effect of High‐Dose Esomeprazole on CYP1A2, CYP2C19, and CYP3A4 Activities in Humans: Evidence for Substantial and Long‐lasting Inhibition of CYP2C19-Reference-Cited by-同舟云学术

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Effect of High‐Dose Esomeprazole on CYP1A2, CYP2C19, and CYP3A4 Activities in Humans: Evidence for Substantial and Long‐lasting Inhibition of CYP2C19

Published:2020-08-02 Issue:6 Volume:108 Page:1254-1264
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Kaartinen Taavi J. K.¹²,Tornio Aleksi¹²³⁴,Tapaninen Tuija¹²,Launiainen Terhi¹,Isoherranen Nina⁵,Niemi Mikko¹²,Backman Janne T.¹²

Affiliation:

1. Department of Clinical Pharmacology Faculty of Medicine University of Helsinki and HUS Helsinki University Hospital Helsinki Finland

2. Individualized Drug Therapy Research Program Faculty of Medicine University of Helsinki Helsinki Finland

3. Integrative Physiology and Pharmacology Institute of Biomedicine, University of Turku Turku Finland

4. Unit of Clinical Pharmacology Turku University Hospital Turku Finland

5. Department of Pharmaceutics School of Pharmacy University of Washington Seattle Washington USA

Funder

Academy of Finland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1949

Reference38 articles.

1. Proton pump inhibitors: an update of their clinical use and pharmacokinetics

2. The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

3. Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies

4. A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers

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4. Association Study of Esomeprazole Pharmacokinetics and CYP2C19 Gene Polymorphisms;Clinical Pharmacology in Drug Development;2023-09-29

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