Common Variants Near ZIC1 and ZIC4 in Autopsy‐Confirmed Multiple System Atrophy

Author:

Hopfner Franziska1ORCID,Tietz Anja K.2,Ruf Viktoria C.3,Ross Owen A.45ORCID,Koga Shunsuke6ORCID,Dickson Dennis6,Aguzzi Adriano7,Attems Johannes8,Beach Thomas9,Beller Allison10,Cheshire William P.11,van Deerlin Vivianna12,Desplats Paula1314,Deuschl Günther2ORCID,Duyckaerts Charles1516,Ellinghaus David17,Evsyukov Valentin1,Flanagan Margaret Ellen1819,Franke Andre17,Frosch Matthew P.202122,Gearing Marla23,Gelpi Ellen2425ORCID,van Gerpen Jay A.11,Ghetti Bernardino26,Glass Jonathan D.27,Grinberg Lea T.28293031,Halliday Glenda32ORCID,Helbig Ingo3334353637,Höllerhage Matthias1,Huitinga Inge3839,Irwin David John40ORCID,Keene Dirk C.10,Kovacs Gabor G.244142,Lee Edward B.43,Levin Johannes444546,Martí Maria J.47484950,Mackenzie Ian5152,McKeith Ian8,Mclean Catriona53,Mollenhauer Brit5455ORCID,Neumann Manuela5657,Newell Kathy L.26,Pantelyat Alex58ORCID,Pendziwiat Manuela5960,Peters Annette61,Molina Porcel Laura62,Rabano Alberto63,Matěj Radoslav6465,Rajput Alex66,Rajput Ali67,Reimann Regina7,Scott William K.68,Seeley William282930,Selvackadunco Sashika69,Simuni Tanya70,Stadelmann Christine71,Svenningsson Per72ORCID,Thomas Alan8,Trenkwalder Claudia5473,Troakes Claire69,Trojanowski John Q.74,Uitti Ryan J.11,White Charles L.75,Wszolek Zbigniew K.11,Xie Tao76,Ximelis Teresa77,Yebenes Justo7879,Müller Ulrich80,Schellenberg Gerard D.12,Herms Jochen34445,Kuhlenbäumer Gregor2,Höglinger Günter14481ORCID,

Affiliation:

1. Department of Neurology Hannover Medical School Hannover Germany

2. Department of Neurology Kiel University Kiel Germany

3. Center for Neuropathology and Prion Research Ludwig‐Maximilians‐Universität Munich Germany

4. Department of Neuroscience Mayo Clinic Jacksonville Florida USA

5. Department of Clinical Genomics Mayo Clinic Jacksonville Florida USA

6. Department of Neuroscience (Neuropathology) Mayo Clinic Jacksonville Florida USA

7. Institute of Neuropathology University Hospital Zürich Zürich Switzerland

8. Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne United Kingdom

9. Banner Sun Health Research Institute Sun City Arizona USA

10. Department of Pathology University of Washington Seattle Washington USA

11. Department of Neurology Mayo Clinic Jacksonville Florida USA

12. Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

13. Department of Neurosciences School of Medicine University of California San Diego La Jolla California USA

14. Department of Pathology School of Medicine University of California San Diego La Jolla California USA

15. Institut du Cerveau, UMR 7225, Sorbonne Université, Paris Brain Institute‐ICM, CNRS, AP‐HP, Hôpital de la Pitié Salpêtrière Inserm U1127 DMU Neurosciences Paris France

16. Brainbank NeuroCEB Neuropathology Network: Plateforme de Ressources Biologiques Hôpital de La Pitié‐Salpêtrière, Bâtiment Roger Baillet Paris Cedex France

17. Institute of Clinical Molecular Biology Christian‐Albrechts‐University of Kiel & University Hospital Schleswig‐Holstein Kiel Germany

18. Mesulam Center for Cognitive Neurology and Alzheimer's Disease Northwestern University Feinberg School of Medicine Chicago Illinois USA

19. Department of Pathology Northwestern University Chicago Illinois USA

20. Department of Neurology Massachusetts General Hospital Boston Massachusetts USA

21. Harvard Medical School Boston Massachusetts USA

22. Department of Pathology Massachusetts General Hospital Boston Massachusetts USA

23. Departments of Pathology and Laboratory Medicine and Neurology Emory University School of Medicine Atlanta Georgia USA

24. Division of Neuropathology and Neurochemistry, Department of Neurology Medical University of Vienna Vienna Austria

25. Medical University of Vienna, Austrian Reference Center for Human Prion Diseases (OERPE) Vienna Austria

26. Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis Indiana USA

27. Department of Neurology Emory University Atlanta Georgia USA

28. Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology University of California San Francisco San Francisco California USA

29. Global Health Institute University of California San Francisco California USA

30. Department of Pathology University of California San Francisco California USA

31. Department of Pathology University of Sao Paulo Medical School Sao Paulo Brazil

32. The University of Sydney School of Medical Sciences, and Brain & Mind Centre Sydney New South Wales Australia

33. Department of Biomedical Informatics Columbia University Irving Medical Center New York New York USA

34. Department of Biomedical and Health Informatics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

35. Division of Neurology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

36. The Epilepsy NeuroGenetics Initiative (ENGIN) Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

37. Department of Neurology, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

38. Department of Neuroimmunology Netherlands Institute for Neuroscience Amsterdam the Netherlands

39. Brain Plasticity Group, Swammerdam Institute for Life Sciences University of Amsterdam Amsterdam the Netherlands

40. Department of Neurology University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA

41. Department of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada

42. Laboratory Medicine Program and Krembil Brain Institute University Health Network Toronto Ontario Canada

43. Department of Pathology and Laboratory Medicine, Translational Neuropathology Research Laboratory Perelman School of Medicine Philadelphia Pennsylvania USA

44. DZNE – German Center for Neurodegenerative Diseases Munich Germany

45. Munich Cluster for Systems Neurology (SyNergy) Munich Germany

46. Department of Neurology Ludwig‐Maximilians‐Universität München Munich Germany

47. Parkinson's Disease and Movement Disorders Unit Department of Neurology, Hospital Clinic of Barcelona Barcelona Spain

48. Institut de Neurociències, Maeztu Center University of Barcelona Barcelona Spain

49. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain

50. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) Barcelona Spain

51. Department of Pathology University of British Columbia Vancouver British Columbia Canada

52. Department of Pathology Vancouver General Hospital Vancouver British Columbia Canada

53. Department of Anatomical Pathology Alfred Health Melbourne Victoria Australia

54. Paracelsus‐Elena‐Klinik Kassel Germany

55. Department of Neurology University Medical Center Goettingen Gottingen Germany

56. Molecular Neuropathology of Neurodegenerative Diseases German Center for Neurodegenerative Diseases Tübingen Germany

57. Department of Neuropathology University Hospital of Tübingen Tübingen Germany

58. Department of Neurology School of Medicine, Johns Hopkins University Baltimore Maryland USA

59. Department of Neuropediatrics Children's Hospital, University Medical Center Schleswig‐Holstein, University of Kiel Kiel Germany

60. Institute of Clinical Molecular Biology Christian‐Albrechts‐University of Kiel Kiel Germany

61. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg Germany

62. Neurology Department, Hospital Clinic, IDIBAPS Barcelona Spain

63. Neuropathology Department, CIEN Foundation Alzheimer's Centre Queen Sofía Foundation Madrid Spain

64. Department of Pathology, 3rd Faculty of Medicine, Charles University University Hospital Kralovske Vinohrady Prague Czech Republic

65. Department of Pathology and Molecular Medicine, 3rd Faculty of Medicine Charles University, Thomayer University Hospital Prague Czech Republic

66. Division of Neurology Royal University Hospital, University of Saskatchewan Saskatoon Saskatchewan Canada

67. Saskatchewan Movement Disorders Program Saskatchewan Health Authority/University of Saskatchewan Saskatoon Saskatchewan Canada

68. John P. Hussman Institute for Human Genomics and Dr. John T. Macdonald Department of Human Genetics University of Miami, Miller School of Medicine Miami Florida USA

69. Basic and Clinical Neuroscience Department Institute of Psychiatry, Psychology and Neuroscience, King's College London London United Kingdom

70. Department of Neurology Northwestern University Feinberg School of Medicine Chicago Illinois USA

71. Institute for Neuropathology University Medical Centre Göttingen Göttingen Germany

72. Section of Neurology, Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden

73. Department of Neurosurgery University Medical Center Goettingen Goettingen Germany

74. Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine Philadelphia Pennsylvania USA

75. Pathology University of Texas Southwestern Medical Center Dallas Texas USA

76. Department of Neurology University of Chicago Medicine Chicago Illinois USA

77. Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona Barcelona Spain

78. Neurological Tissue Bank, Biobanc‐Hospital Clínic‐IDIBAPS Barcelona Spain

79. Servicio de Neurología Hospital Ramón y Cajal de Madrid Madrid Spain

80. Institute of Human Genetics JLU‐Gießen Giessen Germany

81. Zentrum für Systemische Neurowissenschaften Hannover Germany

Funder

Else Kröner-Fresenius-Stiftung

Deutsche Gesellschaft für Parkinson und Bewegungsstörungen

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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