T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy-Reference-Cited by-同舟云学术

T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy

Published:2023-10-23 Issue:11 Volume:10 Page:2149-2154
ISSN:2328-9503
Container-title:Annals of Clinical and Translational Neurology
language:en
Short-container-title:Ann Clin Transl Neurol

Author:

Denis Colin¹^ORCID,Dabbs Kevin¹,Nair Veena A.²,Mathis Jedidiah³,Almane Dace N.¹,Lakshmanan Akshayaa¹,Nencka Andrew³,Birn Rasmus M.²⁴,Conant Lisa⁵,Humphries Colin⁵,Felton Elizabeth¹^ORCID,Raghavan Manoj⁵,DeYoe Edgar A.³⁶,Binder Jeffrey R.⁵⁶,Hermann Bruce¹,Prabhakaran Vivek²,Bendlin Barbara B.⁷,Meyerand Mary E.⁸⁹,Boly Mélanie¹⁴,Struck Aaron F.¹¹⁰^ORCID

Affiliation:

1. Department of Neurology University of Wisconsin‐Madison Madison Wisconsin USA

2. Department of Radiology University of Wisconsin‐Madison Madison Wisconsin USA

3. Department of Radiology Medical College of Wisconsin Milwaukee Wisconsin USA

4. Department of Psychiatry University of Wisconsin‐Madison Madison Wisconsin USA

5. Department of Neurology Medical College of Wisconsin Milwaukee Wisconsin USA

6. Department of Biophysics Medical College of Wisconsin Milwaukee Wisconsin USA

7. Department of Medicine University of Wisconsin‐Madison Madison Wisconsin USA

8. Department of Medical Physics University of Wisconsin‐Madison Madison Wisconsin USA

9. Department of Biomedical Engineering University of Wisconsin‐Madison Madison Wisconsin USA

10. William S. Middleton Veterans Administration Hospital Madison Wisconsin USA

Abstract

AbstractShort‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age‐matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group‐level aberrations in overall myelin content or myelin changes through time in TLE.

Funder

Department of Radiology, University of Wisconsin-Madison

National Institutes of Health

National Institute of Neurological Disorders and Stroke

Publisher

Wiley

Subject

Neurology (clinical),General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/acn3.51653

Reference29 articles.

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5. Preferential susceptibility of limbic cortices to microstructural damage in temporal lobe epilepsy: A quantitative T1 mapping study