Affiliation:
1. State Key Laboratory of Digital Medical Engineering, School of Chemistry and Chemical Engineering Southeast University Nanjing Jiangsu 210096 P. R. China
2. Key Laboratory of Materials for High‐Power Laser, Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 P. R. China
3. Peter Grünberg Research Centre, College of Telecommunications and Information Engineering Nanjing University of Posts and Telecommunications Nanjing Jiangsu 210003 P. R. China
Abstract
AbstractA signal amplification strategy is always required to improve sensing performance, especially for mass‐prepared, miniature and highly sensitive testing equipment. Herein, an on‐chip integrated biosensor combining microcavity lasing and surface enhanced Raman scattering (SERS) for label‐free biochemical analysis is developed. The gallium nitride (GaN) microrings array is fabricated as a whispering gallery mode microlaser based on totally internal wall reflection, and gold nanoparticles (AuNPs) are further assembled on the cavity surface to confine the optical field synergistically. The improvement of lasing capability indicates the strong light‐matter interaction that is conducive to superior response of biomolecules. As a functional example, a GaN/AuNPs substrate is employed in a urine assay, which avoids the shortcomings of requiring specific reactive reagents on different display modules. Ultimately, the chip not only realizes a wide range of pH (3.6–7.8) identification depending on the ultra‐sensitivity feedback of lasing to the refractive index of liquids, but also significantly enhances SERS signals to enable real‐time determination of the biomolecules in human urine. Even the lowest levels of creatinine (0.02%) can be quantitatively detected in less than a minute; thus this work with dual‐mode spectral analyses realizes rapid diagnosis for urinary systems, as well as provides a more accurate reference for the screening of other diseases.
Funder
Fundamental Research Funds for the Central Universities
Subject
Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献