Affiliation:
1. School of Chemistry and Chemical Engineering School of Materials Science and Engineering Institutes of Physical Science and Information Technology Center of Free Electron Laser & High Magnetic Field Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province Anhui University Hefei...
2. School of Chemical and Environmental Engineering Anhui Polytechnic University Wuhu 241000 P. R. China
Abstract
AbstractCommercial photosensitizers (PSs) present great potential in the field of clinical photodynamic therapy (PDT) yet face a formidable challenge owing to the extremely short lifespan of singlet oxygen (1O2). Herein, the 1O2 slow‐release “platform” is proposed based on an anthracene‐groups functionalized D‐π‐A system (AIC), which can capture and slowly release 1O2 produced by commercial PSs. Meanwhile, the reversible chemical process between AIC and 1O2 is demonstrated by a series of optical experiments and high‐resolution mass spectrum. Remarkably, by virtue of 1O2 slow‐release “platform”, the sustaining mitochondrial autophagy and cell apoptosis still take place when the laser is cut off with a short period of irradiation, reducing the side effect of sustained irradiation. In general, the construction of 1O2 slow‐release platform opens up exciting opportunities for improving the PDT effect of commercial PSs.
Funder
National Natural Science Foundation of China
Subject
Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials