Effective extracellular vesicles in glioma: Focusing on effective ncRNA exosomes and immunotherapy methods for treatment

Author:

Al‐Hawary Sulieman Ibraheem Shelash1ORCID,Alhajlah Sharif2,Olegovich Bokov Dmitry34,Hjazi Ahmed5,Rajput Pranchal6,Ali Saad Hayif Jasim7,Abosoda Munther8910,Ihsan Ali11,Oudah Shamam Kareem12,Mustafa Yasser Fakri13ORCID

Affiliation:

1. Department of Business Administration, Business School Al al‐Bayt University Al‐Mafraq Jordan

2. Department of Medical Laboratories, College of Applied Medical Sciences Shaqra University Shaqraa Saudi Arabia

3. Institute of Pharmacy Sechenov First Moscow State Medical University Moscow Russian Federation

4. Laboratory of Food Chemistry, Federal Research Center of Nutrition Biotechnology and Food Safety Moscow Russian Federation

5. Department of Medical Laboratory Sciences, College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Al‐Kharj Saudi Arabia

6. School of Applied and Life Sciences Uttaranchal University Dehradun India

7. Department of Medical Laboratory, College of Health and Medical Technology Al‐Ayen University Thi‐Qar Iraq

8. College of Pharmacy The Islamic University Najaf Iraq

9. College of Pharmacy The Islamic University of Al Diwaniyah Al Diwaniyah Iraq

10. College of Pharmacy The Islamic University of Babylon Babylon Iraq

11. Department of Medical Laboratories Techniques Imam Ja'afar Al‐Sadiq University Iraq

12. College of Pharmacy National University of Science and Technology Dhi Qar Iraq

13. Department of Pharmaceutical Chemistry, College of Pharmacy University of Mosul Mosul Iraq

Abstract

AbstractThis comprehensive article explores the complex field of glioma treatment, with a focus on the important roles of non‐coding RNAsRNAs (ncRNAs) and exosomes, as well as the potential synergies of immunotherapy. The investigation begins by examining the various functions of ncRNAs and their involvement in glioma pathogenesis, progression, and as potential diagnostic biomarkers. Special attention is given to exosomes as carriers of ncRNAs and their intricate dynamics within the tumor microenvironment. The exploration extends to immunotherapy methods, analyzing their mechanisms and clinical implications in the treatment of glioma. By synthesizing these components, the article aims to provide a comprehensive understanding of how ncRNAs, exosomes, and immunotherapy interact, offering valuable insights into the evolving landscape of glioma research and therapeutic strategies.

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,General Medicine,Biochemistry

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