Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1‐OH‐midazolam in morbidly obese and weight loss surgery patients

Author:

Brill MJE12,Välitalo PAJ1,Darwich AS3,van Ramshorst B4,van Dongen HPA5,Rostami–Hodjegan A3,Danhof M1,Knibbe CAJ12

Affiliation:

1. Division of PharmacologyLeiden Academic Centre for Drug Research, Leiden UniversityLeiden The Netherlands

2. Department of Clinical PharmacySt. Antonius HospitalNieuwegein The Netherlands

3. Manchester Pharmacy School, University of ManchesterManchester Great Britain United Kingdom

4. Department of SurgerySt. Antonius HospitalNieuwegein The Netherlands

5. Department of AnaesthesiologyIntensive Care, and Pain Management, St. Antonius HospitalNieuwegein The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

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