Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants

Author:

Emoto C12,Fukuda T12,Mizuno T1,Schniedewind B3,Christians Uwe3,Adams DM24,Vinks AA12

Affiliation:

1. Division of Clinical PharmacologyCincinnati Children's Hospital Medical CenterCincinnati Ohio USA

2. Department of PediatricsUniversity of Cincinnati College of MedicineCincinnati Ohio USA

3. iC42 Integrated Solutions in Clinical Research and Development, University of Colorado, Anschutz Medical CenterAurora Colorado USA

4. Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical CenterCincinnati Ohio USA

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

Reference40 articles.

1. Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus

2. Sirolimus for the treatment of complicated vascular anomalies in children

3. A Phase 2 Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform Neurofibromas (NCT00634270). 2008 March 14 2014 [cited] Available from:

4. A Phase 2 Study — Clinical Trial Assessing Efficacy and Safety of the mTOR Inhibitor Sirolimus in the Treatment of Complicated Vascular Anomalies (NCT00975819). 2009 [cited] Available from:

5. Tips and traps analyzing pediatric PK data

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