Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function-Reference-Cited by-同舟云学术

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Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function

Published:2014-04-15 Issue:6 Volume:44 Page:1737-1746
ISSN:0014-2980
Container-title:European Journal of Immunology
language:en
Short-container-title:Eur. J. Immunol.

Author:

Stumpf Melanie¹²,Zhou Xuyu¹³,Chikuma Shunsuke¹⁴,Bluestone Jeffrey A.¹

Affiliation:

1. Diabetes Center and the Department of Medicine; University of California; San Francisco CA USA

2. Barbara Davis Center for Childhood Diabetes; University of Colorado School of Medicine; Aurora CO USA

3. Institute of Microbiology; Chinese Academy of Sciences; Beijing China

4. Department of Immunology and Genomic Medicine; Graduate School of Medicine, Kyoto University; Japan

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/eji.201343891/fullpdf

Reference58 articles.

1. CTLA-4 ligation blocks CD28-dependent T cell activation;Walunas;J. Exp. Med.,1996

2. CTLA-4 can function as a negative regulator of T cell activation;Walunas;Immunity,1994

3. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells;Krummel;J. Exp. Med.,1996

4. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4;Waterhouse;Science,1995

5. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4;Tivol;Immunity,1995

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