The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes

Author:

Nickerson Michael L.1,Bosley Allen D.2,Weiss Jayne S.3,Kostiha Brittany N.1,Hirota Yoshihisa4,Brandt Wolfgang5,Esposito Dominic6,Kinoshita Shigeru7,Wessjohann Ludger5,Morham Scott G.8,Andresson Thorkell2,Kruth Howard S.9,Okano Toshio4,Dean Michael1

Affiliation:

1. Cancer and Inflammation Program, National Cancer Institute; National Institutes of Health; Frederick; Maryland

2. Laboratory of Proteomics and Analytical Technologies; Advanced Technology Program, SAIC-Frederick, National Cancer Institute, National Institutes of Health; Frederick; Maryland

3. Department of Ophthalmology; Louisiana State University; New Orleans; Louisiana

4. Department of Hygienic Sciences; Kobe Pharmaceutical University; Higashinada-ku; Kobe; Japan

5. Department of Bioorganic Chemistry; Leibniz Institute of Plant Biochemistry; Halle (Saale); Germany

6. Protein Expression Laboratory, Advanced Technology Program, SAIC-Frederick, National Cancer Institute; National Institutes of Health; Frederick; Maryland

7. Department of Ophthalmology; Kyoto Prefectural University of Medicine; Kyoto; Japan

8. MesaGen; LLC; Salt Lake City; Utah

9. Section of Experimental Atherosclerosis; National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda; Maryland

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Reference62 articles.

1. Schnyder corneal dystrophy in a Saudi Arabian family with heterozygous UBIAD1 mutation (p.L121F);Al-Ghadeer;Middle East Afr J Ophthalmol,2011

2. A structural model of the membrane-bound aromatic prenyltransferase UbiA from E. coli;Bräuer;Chembiochem,2008

3. Cholesterol turnover in hereditary crystalline corneal dystrophy of Schnyder;Burns;Tr Am Ophth Soc,1978

4. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR;Calkin;Nat Rev Mol Cell Biol,2012

5. Acyl-coenzyme A: cholesterol acyltransferase;Chang;Annu Rev Biochem,1997

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