The association of perceived discrimination with dementia risk in Black older adults

Author:

Dark Heather E.1,Huang Alison234,Cordon Jenifer1,Deal Jennifer A.345,Palta Priya67,Windham B. Gwen8,Barnes Lisa L.910,Kucharska‐Newton Anna11,Mosley Thomas8,Gottesman Rebecca F.12,Sims Mario8,Griswold Michael813,Arce Rentería Miguel14,Manly Jennifer J.14,Walker Keenan A.1

Affiliation:

1. Laboratory of Behavioral Neuroscience National Institute on Aging Baltimore Maryland USA

2. Department of Mental Health Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

3. Cochlear Center for Hearing & Public Health Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

4. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

5. Department of Otolaryngology‐Head and Neck Surgery Johns Hopkins School of Medicine Baltimore Maryland USA

6. Department of Medicine Columbia University Irving Medical Center New York New York USA

7. Department of Epidemiology Columbia Mailman School of Public Health New York New York USA

8. Department of Medicine University of Mississippi Medical Center Jackson Mississippi USA

9. Department of Neurological Sciences at Rush University Medical Center Chicago Illinois USA

10. Rush Alzheimer's Disease Center at Rush University Medical Center Chicago Illinois USA

11. University of North Carolina Gillings School of Global Public Health Chapel Hill North Carolina USA

12. National Institute of Neurological Disorders and Stroke Intramural Program NIH Bethesda Maryland USA

13. Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

14. Department of Neurology Taub Institute for Research on Alzheimer's Disease and the Aging Brain Vagelos College of Physicians and Surgeons Columbia University New York New York USA

Abstract

AbstractINTRODUCTIONNon‐Hispanic Black, compared to non‐Hispanic White, older adults are at increased risk for dementia. This may be due partly to greater exposure to psychosocial stressors, such as discrimination; however, few studies have examined this association.METHODSWe examined the association of perceived discrimination (e.g., everyday, lifetime, and discrimination burden) with dementia risk in 1583 Black adults co‐enrolled in the Atherosclerosis Risk in Communities (ARIC) Study and the Jackson Heart Study (JHS). Perceived discrimination (defined continuously and using tertiles) was assessed at JHS Exam 1 (2000–2004; mean age ± SD:66.2 ± 5.5) and related to dementia risk through ARIC visit 6 (2017) using covariate‐adjusted Cox proportional hazards models.RESULTSAssociations of perceived everyday, lifetime, and burden of discrimination with dementia risk were not supported in age‐adjusted models or demographic‐ and cardiovascular health‐adjusted models. Results were similar across sex, income, and education.DISCUSSIONIn this sample, associations between perceived discrimination and dementia risk were not supported.Highlights In Black older adults perceived discrimination not associated with dementia risk. Younger age and greater education linked to greater perceived discrimination. Older age and less education among factors associated with dementia risk. Factors increasing exposure to discrimination (education) are also neuroprotective.

Funder

National Heart, Lung, and Blood Institute

U.S. Department of Health and Human Services

National Institutes of Health

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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