Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo

Author:

Geng Jingwei1,Hu Xiaoning2,Zhang Zhongmou3456,Gu Zichen3456,Li Yuanyuan34,Mou Xiaodong34,Mao Lu3456,Ge Yongzhuang3456,Yang Xinyu34,Song Yihui34,Liu Hongmin3456,Wang Linqing7,Wei Zhanyong8,Wang Zhenya3456,Xu Haiwei3456

Affiliation:

1. Zhongyuan District Center for Disease Control and Prevention of Zhengzhou Zhengzhou China

2. Binzhou People's Hospital Binzhou Shandong Province China

3. Collaborative Innovation Center of New Drug Research and Safety Evaluation Henan Province China

4. Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education Zhengzhou University Zhengzhou China

5. Key Laboratory of “Runliang” Antiviral Medicines Research and Development, Institute of Drug Discovery & Development Zhengzhou University Zhengzhou China

6. Institute of Drug Discovery & Development Zhengzhou University Zhengzhou China

7. Zhengzhou Key Laboratory of molecular biology Zhengzhou Normal University Zhengzhou China

8. College of Veterinary Medicine Henan Agricultural University Zhengzhou China

Publisher

Wiley

Subject

Infectious Diseases,Virology

Reference47 articles.

1. Influenza Pandemics: Past, Present and Future

2. Antivirals Targeting Influenza A Virus

3. The nucleoprotein of H7N9 influenza virus positively regulates TRAF3‐mediated innate signaling and attenuates viral virulence in mice;Wei Y;J Virol

4. A history of influenza

5. Structures of influenza A proteins and insights into antiviral drug targets

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