Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies-Reference-Cited by-同舟云学术

Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies

Published:2013-08 Issue:8 Volume:102 Page:2806-2818
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Poulin Patrick,Haddad Sami

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference38 articles.

1. In vitro-in vivo extrapolation of clearance: Modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing methods;Poulin;J Pharm Sci,2012

2. Comparative assessment of in vitro-in vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs;Poulin;J Pharm Sci,2012

3. Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte data;Poulin;J Pharm Sci,2013

4. Prediction of total hepatic clearance by combining metabolism, transport and permeability data in the in vitro-in vivo extrapolation methods: Emphasis on a fraction unbound in liver for drugs;Poulin;J Pharm Sci,2013

5. PhRMA CPCDC initiative on predictive models of human pharmacokinetics. 3. Comparative assessment of prediction methods of human clearance;Ring;J Pharm Sci,2011

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