The importance of preoperative T3 stage substaging by 3D endorectal ultrasonography for the prognosis of middle and low rectal cancer

Abstract

AbstractObjectiveThe study aimed to validate the role of 3D‐endorectal ultrasonography in prognosis and recurrence for patients with T3‐stage rectal cancer by evaluating the preoperative extramural depth of tumor invasion.MethodsIn this study, we investigated the medical records of rectal cancer patients who were admitted to Changhai Hospital's Colorectal Surgery Division. The sample group was categorized into three subgroups (T3a, T3b, and T3c) based on the extent of tumor progression (<5 mm, 5–10 mm, and >10 mm) to assess the endorectal ultrasonography diagnostic performance. The 5‐year disease‐free survival and overall survival were assessed using the Kaplan‐Meier method and a log rank test. Cox regression analysis verified the tumor invasion depth's significance as a prognostic predictor, and it was also utilized to evaluate other independent risk variables for recurrence after surgery.ResultsThe study included 72 individuals with low and middle rectal cancer from January 2014 to November 2019. Twenty‐two individuals had stage T3a, 22 had stage T3b, and 28 had stage T3c based on preoperative endorectal ultrasonography. Endorectal ultrasonography had 88.0%, 86.8%, and 76.2% overall accuracy for stratifying subgroups, respectively. According to the Kaplan‐Meier curve, 5‐year OS was 100%, 83.5%, and 92.9% for T3a, T3b, and T3c (p = 0.172), and 5‐year disease‐free survival was 100%, 80.8%, and 72.9% for T3a, T3b, and T3c, respectively (p = 0.014). A distinct risk factor for 5‐year disease‐free survival was the degree of tumor infiltration (p = 0.039).ConclusionPreoperative T3 stage subdivision allows for categorization of prognosis and survival. Endorectal ultrasonography reports should make explicit declarations of T3a, T3b, and T3c scales.