Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages-Reference-Cited by-同舟云学术

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Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages

Published:2022-01-23 Issue:4 Volume:119 Page:1062-1076
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotech & Bioengineering

Author:

Chang Meiping¹^ORCID,Kumar Amit¹,Kumar Swetha²,Huhn Steven¹^ORCID,Timp Winston³,Betenbaugh Michael²^ORCID,Du Zhimei¹^ORCID

Affiliation:

1. Biologics Process R&D Merck & Co., Inc. Kenilworth New Jersey USA

2. Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore Maryland USA

3. Department of Biomedical Engineering Johns Hopkins University Baltimore Maryland USA

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.28036

Reference75 articles.

1. Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

2. Enhancer DNA methylation: implications for gene regulation

3. The interplay of epigenetic marks during stem cell differentiation and development

4. Valproic acid: A viable alternative to sodium butyrate for enhancing protein expression in mammalian cell cultures

5. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

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1. Genome-Wide CRISPR/Cas9 Screening Unveils a Novel Target ATF7IP–SETDB1 Complex for Enhancing Difficult-to-Express Protein Production;ACS Synthetic Biology;2024-01-19

2. Transcriptomics and cell painting analysis reveals molecular and morphological features associated with fed‐batch production performance in CHO recombinant clones;Biotechnology and Bioengineering;2023-08-09

3. Genomic features of recombinant CHO clones arising from transposon-based and randomized integration;Journal of Biotechnology;2023-08

4. Nanopore Cas9‐targeted sequencing enables accurate and simultaneous identification of transgene integration sites, their structure and epigenetic status in recombinant Chinese hamster ovary cells;Biotechnology and Bioengineering;2023-04-14

5. A proteomics approach to decipher a sticky CHO situation;Biotechnology and Bioengineering;2022-05-25

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