Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis

Author:

Hammerich Linda1,Bangen Jörg M.1,Govaere Olivier2,Zimmermann Henning W.1,Gassler Nikolaus3,Huss Sebastian4,Liedtke Christian1,Prinz Immo5,Lira Sergio A.6,Luedde Tom1,Roskams Tania2,Trautwein Christian1,Heymann Felix1,Tacke Frank1

Affiliation:

1. Department of Medicine III; RWTH University-Hospital Aachen; Aachen Germany

2. Department of Imaging and Pathology; Catholic University of Leuven; Leuven Belgium

3. Institute of Pathology; RWTH University-Hospital Aachen; Aachen Germany

4. Department of Pathology; University of Bonn; Bonn Germany

5. Institute of Immunology; Hannover Medical School; Hannover Germany

6. Immunology Institute; Mount Sinai Medical Center; New York NY

Publisher

Wiley

Subject

Hepatology

Reference29 articles.

1. Liver fibrosis;Bataller;J Clin Invest,2005

2. Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis;Zimmermann;Inflamm Allergy Drug Targets,2011

3. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver;Shields;J Immunol,1999

4. CXCR3 dependent recruitment and CCR6 mediated positioning of Th-17 cells in the inflamed liver;Oo;J Hepatol,2012

5. The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C;Bonacchi;Gastroenterology,2003

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