Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

Author:

Xiao Zhiyan12,Morris-Natschke Susan L.3,Lee Kuo-Hsiung34

Affiliation:

1. Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050 China

2. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050 China

3. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy; University of North Carolina; Chapel Hill NC 27599-7568

4. Chinese Medicine Research and Development Center; China Medical University and Hospital; Taichung Taiwan

Funder

National Natural Science Foundation of China

NIH

Publisher

Wiley

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Reference270 articles.

1. The influence of natural products upon drug discovery;Newman;Nat Prod Rep,2000

2. Statistical investigation into the structural complementarity of natural products and synthetic compounds;Henkel;Angew Chem Int Ed,1999

3. Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry;Feher;J Chem Inf Comput Sci,2003

4. Properties and architecture of drugs and natural products revisited;Grabowski;Curr Chem Biol,2007

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