Zanthoxylum avicennae extract enhances GSK-3β to attenuate β-catenin via phosphatase 2A to block metastatic effects of HA22T cells and hepatocellular carcinoma xenografted nude mice

Author:

Wu Hsi-Chin1,Lay Ing-Shiow23,Shibu Marthandam Asokan4,Ho Tsung-Jung23,Cheng Shiu-Min5,Lin Chih-Hao6,Dung Tran Duc2,Jeng Long-Bin7,Viswanadha Vijaya Padma8,Huang Chih-Yang249

Affiliation:

1. Department of Urology; China Medical University Hospital; Taichung 40402 Taiwan

2. School of Chinese Medicine, College of Chinese Medicine; China Medical University; Taichung 40402 Taiwan

3. Chinese Medicine Department; China Medical University Beigang Hospital; Yunlin County 65152 Taiwan

4. Graduate Institute of Basic Medical Science, China Medical University; Taichung 40402 Taiwan

5. Department of Psychology; Asia University; Taichung Taiwan

6. Department of Information Science and Applications; Asia University; Taichung Taiwan

7. Department of Surgery and Organ Transplantation Center; China Medical University Hospital; Taichung 40447 Taiwan

8. Department of Biotechnology; Bharathiar University; Coimbatore 641 046 India

9. Department of Health and Nutrition Biotechnology; Asia University; Taichung 41354 Taiwan

Funder

Taiwan Department of Health Clinical Trial and Research Center for Excellence

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Toxicology,General Medicine

Reference40 articles.

1. Antitumor effects of dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappa B Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism;Lampiasi;Molecular Pharmacology.,2009

2. Crude extracts of Euchresta formosana radix inhibit invasion and migration of human hepatocellular carcinoma cells;Hsu;Anticancer Res.,2007

3. Targeting the Wnt/beta-Catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535;Gedaly;PLos One.,2014

4. Role of Wnt/beta-catenin signaling in liver metabolism and cancer;Monga;Int J Biochem Cell Biol.,2011

5. Caught up in a Wnt storm: Wnt signaling in cancer;Giles;Biochim Biophys Acta-Rev Cancer.,2003

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