Affiliation:
1. Department of Obstetrics and Gynecology The Affiliated Nanchong Central Hospital of North Sichuan Medical College Nanchong Sichuan China
2. State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering Chongqing Medical University Chongqing China
3. Department of Obstetrics and Gynecology Si Chuan Mian Yang 404 Hospital Mian Yang Sichuan China
4. Department of Radiology The Affiliated Nanchong Central Hospital of North Sichuan Medical College Nanchong Sichuan China
5. Department of Obstetrics and Gynecology The Affiliated Hospital of West Normal University Nanchong Sichuan China
Abstract
BackgroundA referenced MRI‐based classification associated with focused ultrasound ablation surgery (FUAS) outcomes is lacking in adenomyosis.PurposeTo identify an MRI‐based classification system for informing the FUAS outcomes.Study TypeRetrospective.PopulationPatients with FUAS for adenomyosis, were divided into a training set (N = 643; 355 with post‐FUAS gonadotropin‐releasing hormone/levonorgestrel, 288 without post‐FUAS therapy) and an external validation set (N = 135; all without post‐FUAS therapy).Field Strength/Sequence1.5 T, turbo spin‐echo T2‐weighted imaging and single‐shot echo‐planar diffusion‐weighted imaging sequences.AssessmentFive MRI‐based adenomyosis classifications: classification 1 (C1) (diffuse, focal, and mild), C2 (intrinsic, extrinsic, intramural, and indeterminate), C3 (internal, adenomyomas, and external), C4 (six subtypes on areas [internal or external] and volumes [<1/3 or ≥2/3]), and C5 (internal [asymmetric or symmetric], external, intramural, full thickness [asymmetric or symmetric]) for FUAS outcomes (symptom relief and recurrence).Statistical TestsThe optimal classification was significantly associated with the most subtypes of FUAS outcomes. Relating to the timing of recurrence was measured using Cox regression analysis and median recurrence time was estimated by a Kaplan–Meier curve. A P value <0.05 was considered statistically significant.ResultsDysmenorrhea relief and recurrence were only associated with C2 in training patients undergoing FUAS alone. Compared with other subtypes, the extrinsic subtype of C2 was significantly associated with dysmenorrhea recurrence in the FUAS group. Besides, the median dysmenorrhea recurrence time of extrinsic subtype was significantly shorter than that of other subtypes (42.0 months vs. 50.3 months). In the validation cohort, C2 was confirmed as the optimal system and its extrinsic subtype was confirmed to have a significantly shorter dysmenorrhea recurrence time than other subtypes.Data ConclusionClassification 2 can inform dysmenorrhea relief and recurrence in patients with adenomyosis undergoing FAUS only. Itsextrinsic subtype was associated with an earlier onset of dysmenorrhea recurrence after treatment.Evidence Level3Technical EfficacyStage 5
Funder
National Natural Science Foundation of China
Subject
Radiology, Nuclear Medicine and imaging
Cited by
1 articles.
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