Affiliation:
1. Department of Breast and Thyroid Surgery, West China Hospital, Sichuan University, Sichuan, China
2. The Second People's Hospital of Sichuan, Sichuan, China
Abstract
Abstract
Background
Ischaemia and necrosis of skin flaps is a common complication after mastectomy. This study evaluated the influence of anisodamine and Salvia miltiorrhiza on wound complications after mastectomy for breast cancer.
Methods
Ninety patients undergoing mastectomy for breast carcinoma were divided into three groups. Group 1 received routine wound care, group 2 received intravenous Salvia miltiorrhiza after surgery for 3 days and group 3 similarly received intravenous anisodamine. Skin flaps were observed on postoperative days 4 and 8; areas of wound ischaemia and necrosis were graded and adverse events recorded.
Results
There was no difference in demographic characteristics between the groups. At 4 days after surgery the rate of ischaemia and necrosis in groups 2 and 3 was significantly reduced compared with that in control group 1 (median wound score 6·80 versus 23·38, P = 0·002, and 3·76 versus 23·38, P < 0·001, respectively). This improvement in groups 2 and 3 continued to postoperative day 8 (both P < 0·001), but wound scores at this stage were better in group 3 than in group 2 (1·82 versus 6·92 respectively; P = 0·022). The volume of wound drainage was lower in group 3 than in group 1 (P = 0·004). The incidence of adverse effects was highest in group 3, and two patients in this group discontinued treatment. No significant complications were noted in group 2.
Conclusion
Anisodamine and S. miltiorrhiza were both effective in reducing skin flap ischaemia and necrosis after mastectomy, although anisodamine was associated with a higher rate of adverse effects.
Publisher
Oxford University Press (OUP)
Reference26 articles.
1. Hyperbaric oxygenation and antioxidant vitamin combination reduces ischemia–reperfusion injury in a rat epigastric island skin-flap model;Tomur;J Basic Clin Physiol Pharmacol,2005
2. Biological effect of far-infrared therapy on increasing skin microcirculation in rats;Yu;Photodermatol Photoimmunol Photomed,2006
3. The pharmacological properties of anisodamine;Poupko;J Appl Toxicol,2007
4. [Effects of anisodamine on microcirculation of the asystolic rats during the cardiopulmonary resuscitation.];Jia;Zhongguo Wei Zhong Bing Ji Jiu Yi Xue,2008
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献