Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium

Author:

Verma Shefali Setia1,Bergmeijer Thomas O.2,Gong Li3,Reny Jean‐Luc4567,Lewis Joshua P.8,Mitchell Braxton D.89,Alexopoulos Dimitrios10,Aradi Daniel11,Altman Russ B.12,Bliden Kevin13,Bradford Yuki1,Campo Gianluca14,Chang Kiyuk15,Cleator John H.16,Déry Jean‐Pierre17,Dridi Nadia P.18,Fernandez‐Cadenas Israel19,Fontana Pierre37,Gawaz Meinrad20,Geisler Tobias21,Gensini Gian Franco22,Giusti Betti22,Gurbel Paul A.13,Hochholzer Willibald23,Holmvang Lene18,Kim Eun‐Young24,Kim Ho‐Sook24,Marcucci Rossella22,Montaner Joan25,Backman Joshua D.8,Pakyz Ruth E.8,Roden Dan M.26,Schaeffeler Elke27,Schwab Matthias2728,Shin Jae Gook2429,Siller‐Matula Jolanta M.3031,ten Berg Jurriën M.2,Trenk Dietmar2332,Valgimigli Marco33,Wallace John34,Wen Ming‐Shien35,Kubo Michiaki36,Lee Ming Ta Michael37,Whaley Ryan3,Winter Stefan27,Klein Teri E.338,Shuldiner Alan R.8,Ritchie Marylyn D.1,

Affiliation:

1. Department of Genetics and Institute for Biomedical Informatics University of Pennsylvania Philadelphia Pennsylvania USA

2. Department of Cardiology St. Antonius Center for Platelet Function Research Nieuwegein The Netherlands

3. Department of Biomedical Data Science Stanford University Stanford California USA

4. Internal Medicine Béziers Hospital Béziers France

5. Geneva Platelet Group School of Medicine University of Geneva Geneva Switzerland

6. Department of Internal Medicine, Rehabilitation and Geriatrics University Hospitals of Geneva Geneva Switzerland

7. Geneva Platelet Group and Division of Angiology and Haemostasis University Hospitals of Geneva Geneva Switzerland

8. Department of Medicine and Program for Personalized and Genomic Medicine University of Maryland Baltimore Maryland USA

9. Geriatrics Research and Education Clinical Center Baltimore Veterans Administration Medical Center Baltimore Maryland USA

10. National and Kapodistrian University of Athens Medical School Attikon University Hospital Athens Greece

11. Department of Cardiology Heart Center Balatonfüred Balatonfüred Hungary

12. Department of Bioengineering, Genetics and Medicine Stanford University Stanford California USA

13. Sinai Center for Thrombosis Research and Drug Development Baltimore Maryland USA

14. Cardiology Unit Azienda Ospedaliero‐Universitaria di Ferrara Ferrara and Maria Cecilia Hospital GVM Care and Research Cotignola Italy

15. Department of Internal Medicine Cardiology Division Seoul St. Mary's Hospital The Catholic University of Korea Seoul South Korea

16. Division of Cardiology and Department of Pharmacology Vanderbilt University Medical Center Nashville Tennessee USA

17. Quebec Heart and Lung Institute University Laval Quebec City QC Canada

18. Department of Cardiology RigshospitaletCopenhagen University Hospital Copenhagen Denmark

19. Neurology, Stroke Pharmacogenomics and Genetics Group Sant Pau Institute of Research Barcelona Spain

20. Department of Cardiology and Angiology University of Tübingen Tübingen Germany

21. Department of Cardiology and Angiology Medizinische Klinik III University Hospital Tübingen Tübingen Germany

22. Department of Experimental and Clinical Medicine University of Florence Florence Italy

23. Department of Cardiology and Angiology II University Heart Center Freiburg Bad Krozingen Bad Krozingen Germany

24. Department of Clinical Pharmacology Inje UniversityBusan Paik Hospital Busan South Korea

25. Neurovascular Research Laboratory Vall d'Hebron Institute of Research Barcelona Spain

26. Medicine, Pharmacology, and Biomedical Informatics Vanderbilt University Medical Center Nashville Tennessee USA

27. Dr. Margarete Fischer‐Bosch Institute of Clinical Pharmacology and University of Tübingen Tübingen Germany

28. Department of Clinical Pharmacology, and Pharmacy and Biochemistry University of Tübingen Tübingen Germany

29. Department of Pharmacology and Pharmacogenomics Research Center Inje UniversityBusan Paik Hospital Busan South Korea

30. Department of Internal Medicine II Division of Cardiology Medical University of Vienna Vienna Austria

31. Department of Experimental and Clinical Pharmacology Centre for Preclinical Research and Technology (CEPT) Medical University of Warsaw Warsaw Poland

32. Department of Clinical Pharmacology University Heart Centre Freiburg Bad Krozingen Germany

33. Department of Cardiology, Swiss Cardiovascular Center Bern Bern University Hospital Bern Switzerland

34. Department of Biochemistry and Molecular Biology Penn State University University Park Pennsylvania USA

35. Division of Cardiology, Department of Internal Medicine Chang Gung Memorial Hospital Linkou and School of Medicine Chang Gung University Taoyuan City Taiwan

36. Center for Integrative Medical Sciences RIKEN Yokohama Japan

37. Genomic Medicine Institute Geisinger Danville Pennsylvania USA

38. Department of Medicine Stanford University Stanford California USA

Funder

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

Robert Bosch Stiftung

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

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