Monitoring of optical properties of tumors during laser plasmon photothermal therapy-Reference-Cited by-同舟云学术

Monitoring of optical properties of tumors during laser plasmon photothermal therapy

Published:2024-01-14 Issue: Volume: Page:
ISSN:1864-063X
Container-title:Journal of Biophotonics
language:en
Short-container-title:Journal of Biophotonics

Author:

Genin Vadim D.¹²^ORCID,Bucharskaya Alla B.²³^ORCID,Kirillin Mikhail Yu.⁴⁵^ORCID,Kurakina Daria A.⁴^ORCID,Navolokin Nikita A.³^ORCID,Terentyuk Georgy S.³^ORCID,Khlebtsov Boris N.⁶^ORCID,Khlebtsov Nikolai G.¹⁶^ORCID,Maslyakova Galina N.³^ORCID,Tuchin Valery V.¹²⁷^ORCID,Genina Elina A.¹²^ORCID

Affiliation:

1. Optics and Biophotonics Department Saratov State University Saratov Russia

2. Laboratory of Laser Molecular Imaging and Machine Learning Tomsk State University Tomsk Russia

3. Core Facility of Experimental Oncology Saratov State Medical University named after V. I. Razumovsky Saratov Russia

4. Biophotonics Laboratory Institute of Applied Physics Russian Academy of Sciences Nizhny Novgorod Russia

5. Applied Mathematics Department Lobachevsky State University of Nizhny Novgorod Nizhny Novgorod Russia

6. Laboratory of Nanobiotechnology Institute of Biochemistry and Physiology of Plants and Microorganisms, Federal Research Centre “Saratov Scientific Centre of the Russian Academy of Sciences” (IBPPM RAS) Saratov Russia

7. Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control, Federal Research Centre “Saratov Scientific Centre of the Russian Academy of Sciences” Saratov Russia

Abstract

AbstractWe studied grafted tumors obtained by subcutaneous implantation of kidney cancer cells into male white rats. Gold nanorods with a plasmon resonance of about 800 nm were injected intratumorally for photothermal heating. Experimental irradiation of tumors was carried out percutaneously using a near‐infrared diode laser. Changes in the optical properties of the studied tissues in the spectral range 350–2200 nm under plasmonic photothermal therapy (PPT) were studied. Analysis of the observed changes in the absorption bands of water and hemoglobin made it possible to estimate the depth of thermal damage to the tumor. A significant decrease in absorption peaks was observed in the spectrum of the upper peripheral part and especially the tumor capsule. The obtained changes in the optical properties of tissues under laser irradiation can be used to optimize laboratory and clinical PPT procedures.

Funder

Russian Science Foundation

Ministry of Science and Higher Education of the Russian Federation

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Materials Science,General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbio.202300322

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