Effect of photobiomodulation on alleviating primary dysmenorrhea caused by PGF

Author:

Fu Qiqi1,Yang Jiali1,Jiang Hui2,Lin Shangfei2,Qin Haokuan2,Zhao Jie1,Wang Yanqing3,Liu Muqing14ORCID

Affiliation:

1. School of Information Science and Technology Fudan University Shanghai China

2. Academy for Engineering and Technology Fudan University Shanghai China

3. School of Basic Medical Science Fudan University Shanghai China

4. Zhongshan Fudan Joint Innovation Center Zhongshan Guangdong Province China

Abstract

AbstractPhotobiomodulation (PBM) has attracted widespread attention in suppressing various pain and inflammation. Primary dysmenorrhea (PD) primarily occurs in adolescents and adult females, and the limited effectiveness and side effects of conventional treatments have highlighted the urgent need to develop and identify new adjunct therapeutic strategies. In this work, the results of pain and PGs demonstrated that 850 nm, 630 nm, and 460 nm all exhibited pain inhibition, decreased PGF and upregulated PGE2, while 630 nm PBM has better effectiveness. Then to explore the underlying biological mechanisms of red light PBM on PD, we irradiated prostaglandin‐F induced HUSM cells and found that low‐level irradiance can restore intracellular calcium ion, ROS, ATP, and MMP levels to normal levels. And, red light enhanced cell viability and promoted cell proliferation for normal HUSM cells. Therefore, this study proposes that red light PBM may be a promising approach for the future clinical treatment of PD.

Funder

National Key Research and Development Program of China

Publisher

Wiley

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