Photoinduced [3+2] Cycloaddition of Carbenes and Nitriles: A Versatile Approach to Oxazole Synthesis

Author:

Saha Argha1,Sen Chiranjit1,Guin Srimanta1,Das Chandan1,Maiti Debajit2,Sen Subhabrata2,Maiti Debabrata1ORCID

Affiliation:

1. Department of Chemistry Indian Institute of Technology Bombay Powai Mumbai 400076 India

2. Department of Chemistry School of Natural Sciences Shiv Nadar University Uttar Pradesh 201314 India

Abstract

AbstractWe have developed a photoinduced protocol for the synthesis of pharmaceutically important oxazole molecules using diazo‐ and nitrile‐containing reactants. The process involves the initial photolysis of the diazo compound to afford singlet carbenes, which are tapped by nitriles in a [3+2] cycloaddition fashion to give substituted oxazoles. With di‐nitrile compounds, useful bis‐oxazoles were obtained. The applicability of the transformation is showcased through the expedient synthesis of small‐molecule drugs and biologically relevant molecules such as felbinac, pimprinine, texamine, ugnenenazole etc. The protocol is also useful for the generation of 2H and 13C isotope labelled oxazoles. Merging photolysis with continuous‐flow chemistry was demonstrated for scaling up the reaction. The non‐requirement of metal catalysis or photosensitizers to harness the light energy with blue light sufficing the execution of the reaction makes it a versatile and general protocol for the synthesis of structurally diverse oxazoles

Publisher

Wiley

Subject

General Medicine

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