Epidemiology of cervical cancer in elderly women: Analysis of incidence, treatment, and survival using German registry data

Author:

Neumeyer Sonja1ORCID,Tanaka Luana Fiengo1ORCID,Liang Linda A.1ORCID,Klug Stefanie J.1ORCID

Affiliation:

1. Chair of Epidemiology, Department of Sport and Health Sciences Technical University of Munich Munich Germany

Abstract

AbstractBackgroundCervical cancer (CC) screening is generally recommended until age 65. The incidence of CC could be underestimated, particularly in older women, due to a lack of hysterectomy correction. Furthermore, elderly women (≥65 years) are more often diagnosed with late‐stage disease and have worse outcomes than younger patients. This study aims to provide an in‐depth overview of CC in Germany.MethodsIncidence rates of CC (ICD‐10 C53) were determined using data from the German Centre of Cancer Registry data (ZfKD) of six federal state registries. Incidence was corrected by using hysterectomy prevalence values from a real‐world study. The distribution of treatment modalities (surgery, chemotherapy, radiation therapy) was assessed. Relative survival was calculated using the period approach (2011–2015). Survival was stratified by tumor (T) stage and histological type.ResultsIn total, 14,528 CC cases were included, 27.6% of which occurred in elderly women. Cumulative (2001–2015) age‐standardized incidence rates were 12.5 per 100,000 women without hysterectomy correction and 15.5 per 100,000 women after hysterectomy correction (+24% relative change). A lower proportion of elderly women were treated, especially in advanced tumor stages. Younger women (20–64 years) had a higher 5‐year relative survival compared to elderly women: 76.7% versus 46.9%, respectively. Survival was worse with increasing stage and for glandular histological subgroups, particularly among elderly women.ConclusionsCC incidence in elderly women is underestimated and survival is lower compared to younger women in Germany. Due to the high disease burden in elderly women, screening and treatment strategies need to be improved.

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Reference52 articles.

1. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

2. Burden of cervical cancer in Europe: estimates for 2004

3. Robert Koch‐Institut (Hrsg) & die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (Hrsg). Krebs in Deutschland für 2017/2018. In: Ausgabe editor. Robert Koch‐Institut;2021. [Accessed 14 May 2022]. Available from:https://doi.org/10.25646/8353

4. Cervical Screening at Age 50–64 Years and the Risk of Cervical Cancer at Age 65 Years and Older: Population-Based Case Control Study

5. Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society

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