Awakening dormant glycosyltransferases in CHO cells with CRISPRa-Reference-Cited by-同舟云学术

Awakening dormant glycosyltransferases in CHO cells with CRISPRa

Published:2019-11-12 Issue:2 Volume:117 Page:593-598
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Karottki Karen Julie la Cour¹,Hefzi Hooman²³,Xiong Kai¹,Shamie Isaac²³,Hansen Anders Holmgaard¹,Li Songyuan¹,Pedersen Lasse Ebdrup¹^ORCID,Li Shangzhong²³⁴^ORCID,Lee Jae Seong⁵^ORCID,Lee Gyun Min¹⁶^ORCID,Kildegaard Helene Faustrup¹^ORCID,Lewis Nathan E.²³⁴^ORCID

Affiliation:

1. The Novo Nordisk Foundation Center for BiosustainabilityTechnical University of Denmark Kongens Lyngby Denmark

2. Department of PediatricsUniversity of California San Diego San Diego California

3. The Novo Nordisk Foundation Center for BiosustainabilityUniversity of California San Diego San Diego California

4. Department of BioengineeringUniversity of California San Diego San Diego California

5. Department of Molecular Science and TechnologyAjou University Suwon Republic of Korea

6. Department of Biological SciencesKAIST Daejeon Republic of Korea

Funder

Novo Nordisk Fonden

National Institute of General Medical Sciences

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27199

Reference21 articles.

1. Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles

2. The choice of mammalian cell host and possibilities for glycosylation engineering

3. Comparison of Cas9 activators in multiple species

4. Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

5. Modulating carbohydrate–protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology

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