1. Institute for Clinical Chemistry; Universitätsmedizin Mannheim, Medical Faculty Mannheim, University of Heidelberg; Mannheim 68167 Germany
2. Department of Medical; Medical Center Mannheim, Universitätsmedizin Mannheim, University of Heidelberg; Mannheim Germany
3. Division of Clinical Epidemiology and Aging Research; German Cancer Research Center (DKFZ); Heidelberg 69120 Germany
4. Department of Theoretical and Applied Sciences; Insubria University; Varese Italy
5. Division of Theoretical Bioinformatics; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224; Heidelberg Germany