Targeting the wee1 kinase for treatment of pediatric Down syndrome acute myeloid leukemia

Author:

Caldwell J. Timothy12,Edwards Holly34,Buck Steven A.5,Ge Yubin34,Taub Jeffrey W.56

Affiliation:

1. MD/PhD Program; Wayne State University School of Medicine; Detroit Michigan

2. Cancer Biology Graduate Program; Wayne State University School of Medicine; Detroit Michigan

3. Department of Oncology; Wayne State University School of Medicine; Detroit Michigan

4. Molecular Therapeutics Program; Barbara Ann Karmanos Cancer Institute; Detroit Michigan

5. Division of Pediatric Hematology/Oncology; Children's Hospital of Michigan; Detroit Michigan

6. Department of Pediatrics; Wayne State University School of Medicine; Detroit Michigan

Funder

National Cancer Institute

Karmanos Cancer Institute

Children's Research Center of Michigan

Kids Without Cancer, Children's Leukemia Foundation of Michigan

Elana Fund

Herrick Foundation

Justin's Gift Charity

The Buric Family

Leukemia and Lymphoma Society

Sehn Family Foundation

Dale Meyer Memorial Endowment for Leukemia Research

Ring Screw Textron Endowed Chair for Pediatric Cancer Research

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology, and Child Health

Reference43 articles.

1. Down syndrome and malignancies: A unique clinical relationship: A paper from the 2008 William Beaumont hospital symposium on molecular pathology;Xavier;JMD,2009

2. The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines;Ge;Cancer Res,2004

3. GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia;Ge;J Natl Cancer Inst,2005

4. Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-d-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: A model of leukemia in Down syndrome;Taub;Cancer Res,2000

5. Enhanced metabolism of 1-beta-d-arabinofuranosylcytosine in Down syndrome cells: A contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia;Taub;Blood,1996

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