Interpenetrating polymer network based hydrogel: A smart approach for corroborating wound healing of various capacity

Abstract

AbstractHemorrhage of high intensity usually leads to severe mortality accidents, disaster, and warfare. The concomitant wound thereby induces immense psychological as well as physical trauma to the patients. Hence, a faster hemostasis with smart wound healing approaches are highly essential to deal such critical/life threatening situations. The traditional approaches such as implementation of gauze and bandages are found to be having limited scope for controlling hemorrhage, because of non‐biodegradability, high susceptibility towards infection, unsuitability for irregular wound and ineffective towards wound healing. By virtue of the merits revealed by remodeling interpenetrating polymer network (IPN) based hydrogels (biocompatibility, high porosity, tunability, biomimetic and better retention, and proliferative wound healing tendency), have drawn a rigorous attention to out play their ancestors. This review includes the involvement of numerous synthetic routes, types and physicochemical properties of IPN based hydrogels loaded with diverse therapeutic agents towards wound repair/healing. Moreover, some of the recent patents have been portrayed in the manuscript, dignifying the potentiality of fascinating IPN hydrogels towards effective wound healing. More research is required to engineer multifaceted IPN hydrogels to attain huge potential against the challenges and future perspectives in wound healing.