Affiliation:
1. Jiangsu Co‐Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering Nanjing Forestry University Nanjing China
2. Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro‐Forest Biomass Nanjing Forestry University Nanjing China
Abstract
AbstractDesign and fabrication of pH‐responsive nanofibrous membranes by biomaterials is a key step for drug delivery systems. Currently, there is an increasing attention on design of biocompatible nanofibrous drug delivery systems. Here, a bio‐based pH‐responsive nanofibrous membranes loaded with antibiotic were fabricated for the controlled release of tetracycline hydrochloride (TH). The in vitro drug release behavior of varied pH‐responsive nanofibrous with different mass ratios of poly (lactic acid) (PLA) and cellulose acetate phthalate (CAP) was investigated to clarify the release mechanism. TH initial burst release within 20 mins was large than 97.5% for PLA/CAP/TH NFM under alkaline conditions (pH = 8). The antioxidant activity of TH loaded PLA/CAP NFMs are all higher than 55% after 30 mins. The prepared fibrous membranes possess sufficient antibacterial activity against both to Gram‐negative and Gram‐positive bacteria. At the same time, it also has good biocompatibility. Therefore, the fabricated nanofibrous membranes was demonstrated to be a pH‐responsive nanoplatform for drug delivery.
Funder
National Natural Science Foundation of China
Innovative Research Group Project of the National Natural Science Foundation of China
Natural Science Research of Jiangsu Higher Education Institutions of China