Degradation protection and enhanced biocompatibility of Mg alloys pretreated with plasma proteins

Author:

Wei Xian123,Meng Jiajia2,Ma Sujie2,Li Yanchun2,Qing Hong1,Peng Xubiao2,Zhao Qing24ORCID

Affiliation:

1. School of Life Science Beijing Institute of Technology Beijing China

2. School of Physics Beijing Institute of Technology Beijing China

3. Department of Science Taiyuan Institute of Technology Taiyuan China

4. National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing China

Abstract

AbstractAfter implantation of the Mg alloy in the human body, the adsorption of plasma protein on surface will cause a series of cell reactions and affect the degradation of Mg alloys. Herein, in vitro biological reactions of the ZK60 and AZ31 Mg alloys are analyzed in plasma protein environment. Combined with mass spectrometry analysis of the type of adsorbed proteins, it is shown that proteins such as fibrinogen, vitronectin, fibronectin, and prothrombin are prone to get adsorbed on the surface of the alloys than other proteins, leading to the promotion of MG63 cell adhesion and proliferation. The effect of selected proteins (fibrinogen, fibronectin, and prothrombin) on degradation of ZK60 and AZ31 Mg alloys is investigated using immersion tests. The degradation of AZ31 Mg alloy is significantly restrained with the presence of proteins. This is due to the protein adsorption effect on the sample surface. The molecular dynamics simulation results indicate that both fibrinogen and fibronectin tend to adsorb onto the AZ31 rather than ZK60, forming a stable protein layer on the AZ31 Mg alloy retarding the degradation of the samples. As to ZK60 alloy, the addition of protein inhibits the degradation in the short term, however, the degradation increases after a long time of immersion. This phenomenon is particularly pronounced in fibronectin solution.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Wiley

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