Extent of thyroidectomy and paratracheal lymph node dissection in total pharyngolaryngectomy for pyriform sinus cancer, and recurrence, survival, and postoperative hypoparathyroidism: A multicenter retrospective study-Reference-Cited by-同舟云学术

Extent of thyroidectomy and paratracheal lymph node dissection in total pharyngolaryngectomy for pyriform sinus cancer, and recurrence, survival, and postoperative hypoparathyroidism: A multicenter retrospective study

Published:2023-11-13 Issue:2 Volume:46 Page:269-281
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Ariizumi Yosuke¹^ORCID,Hanai Nobuhiro²,Asakage Takahiro¹,Seto Akira³,Tomioka Toshifumi⁴^ORCID,Miyabe Junji⁵,Kessoku Hisashi⁶,Mukaigawa Takashi⁷,Omura Go⁸^ORCID,Teshima Masanori⁹^ORCID,Nishikawa Daisuke²,Saito Yuki¹⁰,Asada Yukinori¹¹,Fujisawa Takuo¹²,Makino Takuma¹³,Nishino Hiroshi¹⁴,Sano Daisuke¹⁵^ORCID,Nakahira Mitsuhiko¹⁶,Tokashiki Kunihiko¹⁷,Uemura Hirokazu¹⁸,Ueda Tsutomu¹⁹^ORCID,Sakai Akihiro²⁰,Masuda Muneyuki²¹,Tsujikawa Takahiro²²^ORCID,Hiei Yusuke²³,Nishio Naoki²⁴^ORCID,Matsui Hidetoshi²⁵,Kiyota Naomi²⁶^ORCID,Homma Akihiro²⁷^ORCID

Affiliation:

1. Department of Head and Neck Surgery Tokyo Medical and Dental University Tokyo Japan

2. Department of Head and Neck Surgery Aichi Cancer Center Hospital Nagoya Japan

3. Division of Head and Neck Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan

4. Department of Head and Neck Surgery National Cancer Center Hospital East Kashiwa Japan

5. Department of Head and Neck Surgery Osaka International Cancer Institute Osaka Japan

6. Department of Otorhinolaryngology The Jikei University School of Medicine Tokyo Japan

7. Division of Head and Neck Surgery Shizuoka Cancer Center Shizuoka Japan

8. Department of Head and Neck Surgery National Cancer Center Hospital Tokyo Japan

9. Department of Otolaryngology – Head and Neck Surgery Kobe University Graduate School of Medicine Kobe Japan

10. Department of Otolaryngology – Head and Neck Surgery University of Tokyo Tokyo Japan

11. Department of Head and Neck Surgery Miyagi Cancer Center Natori Japan

12. Department of Otorhinolaryngology – Head and Neck Surgery Kansai Medical University Osaka Japan

13. Department of Otolaryngology – Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan

14. Otolaryngology Head and Neck Surgery Jichi Medical University Shimotsuke City Japan

15. Department of Otorhinolaryngology – Head and Neck Surgery Yokohama City University School of Medicine Yokohama Japan

16. Department of Head Neck Surgery Saitama Medical University International Medical Cancer Saitama Japan

17. Department of Head and Neck Surgery Tokyo Medical University Tokyo Japan

18. Department of Otolaryngology – Head and Neck Surgery Nara Medical University Kashihara Japan

19. Department of Otorhinolaryngology – Head and Neck Surgery Hiroshima University Hospital Hiroshima Japan

20. Department of Otolaryngology – Head and Neck Surgery Tokai University Isehara Japan

21. Department of Head and Neck Surgery National Hospital Organization Kyushu Cancer Center Fukuoka Japan

22. Department of Otolaryngology – Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan

23. Department of Otolaryngology – Head and Neck Surgery, School of Medicine Fujita Health University Toyoake Japan

24. Department of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya Japan

25. Department of Head and Neck Surgery Hyogo Cancer Center Akashi Japan

26. Department of Medical Oncology and Hematology Kobe University Hospital Kobe Japan

27. Department of Otolaryngology – Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan

Abstract

AbstractBackgroundTotal pharyngolaryngectomy (TPL) is standard treatment for hypopharyngeal cancer. However, extensive thyroidectomy and paratracheal nodal dissection (PTND) can cause hypoparathyroidism. We sought to determine the optimum extent of resection.MethodsWe analyzed the clinicopathological information of 161 pyriform sinus cancer patients undergoing TPL from 25 Japanese institutions. Rates of recurrence and risk factors for hypoparathyroidism, as well as incidence of pathological contralateral level VI nodal metastasis and stomal recurrence, were investigated.ResultsThe extent of thyroidectomy and nodal dissection were not independent risk factors for recurrence. Incidences of contralateral level VI nodal involvement and stomal recurrence were 1.8% and 1.2%, respectively. Patients undergoing hemithyroidectomy/ipsilateral PTND did not develop stomal recurrence and had the lowest incidence of hypoparathyroidism. Prognosis in patients without tracheostomy prior to hemithyroidectomy/ipsilateral PTND was comparable to that with more extensive resections.ConclusionsHemithyroidectomy/ipsilateral PTND may be sufficient for pyriform sinus cancer cases without tracheostomy.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27572

Reference44 articles.

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