Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations

Author:

Costa Ana Carolina Conchon12ORCID,Yamamoto Priscila Akemi3,Lauretti Gabriela Rocha4,Benzi Jhohann Richard1,Zanelli Cleslei Fernando3,Barz Vivien2,Ciarimboli Giuliano2,Moraes Natália Valadares3ORCID

Affiliation:

1. School of Pharmaceutical Sciences of Ribeirão PretoUSP–São Paulo University Ribeirão Preto SP Brazil

2. Experimental Nephrology, Medicine Clinic DUniversity Hospital Münster Münster Germany

3. School of Pharmaceutical SciencesUNESP–São Paulo State University Araraquara SP Brazil

4. School of Medicine of Ribeirão PretoUSP–São Paulo University Ribeirão Preto SP Brazil

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference69 articles.

1. Gabapentin add‐on for drug‐resistant focal epilepsy;Panebianco M;Cochrane Database Syst Rev,2018

2. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

3. KammermanPR FinnerupNB deLimaL et al.Gabapentin for neuropathic pain: an application to the 21st meeting of the WHO Expert Committee on Selection and Use of Essential Medicines for the inclusion of gabapentin on the WHO Model List of Essential Medicines.2016.https://doi.org/10.6084/m9figshare.3814206.v2http://www.who.int/selection_medicines/committees/expert/21/applications/s2_gabapentin.pdfAccessed July 7 2017.

4. The intestinal absorption mechanism of gabapentin makes it appropriate for gastroretentive delivery;Chen C;Curr Clin Pharmacol,2013

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