Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17β-estradiol biosynthesis in endometrial carcinoma microenvironment

Author:

Che Qi1,Liu Bin-Ya1,Liao Yun1,Zhang Hui-Juan2,Yang Ting-Ting1,He Yin-Yan1,Xia Yu-Hong3,Lu Wen1,He Xiao-Ying3,Chen Zheng1,Wang Fang-Yuan1,Wan Xiao-Ping1

Affiliation:

1. Department of Obstetrics and Gynecology; Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University; Shanghai China

2. Department of Pathology; International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai China

3. Department of Obstetrics and Gynecology; International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai China

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference38 articles.

1. Cancer statistics, 2012;Siegel;CA Cancer J Clin,2012

2. Molecular and pathologic aspects of endometrial carcinogenesis;Hecht;J Clin Oncol,2006

3. Relationship between tumour aromatase activity, tumour characteristics and response to therapy;Miller;J Steroid Biochem Mol Biol,1990

4. Tumor estrogen content and clinico-morphological and endocrine features of endometrial cancer;Berstein;J Cancer Res Clin Oncol,2003

5. Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies;Watanabe;Am J Pathol,1995

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