Affiliation:
1. College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou China
Abstract
AbstractAn efficient method for the synthesis of 2‐amino‐4‐aryl‐6‐styrylpyrimidines by the reactions of various distyryl ketones with guanidine hydrochloride through aza‐Michael addition/nucleophilic addition/dehydrogenation cascade processes is described. The salient features of this protocol are the use of easy‐to‐obtain substrates, transition‐metal‐free system, mild reaction conditions, high atom economy, wide substrate scope, satisfactory yield, and simple work‐up procedures.
Funder
National Natural Science Foundation of China